Clinical relevance of interictal dysphoric disorder and its impact on quality of life in drug-resistant epilepsy

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• dc.contributor.author Monteagudo-Gimeno, Eila
• dc.contributor.author Sánchez-González, Roberto
• dc.contributor.author Raduà Castaño, Joaquim
• dc.contributor.author Fortea-González, Lydia
• dc.contributor.author Boget Llucià, Teresa
• dc.contributor.author Carreño Martínez, Mar
• dc.contributor.author Donaire Pedraza, Antonio J.
• dc.contributor.author Bargalló Alabart, Núria
• dc.contributor.author Setoain Perego, Xavier
• dc.contributor.author Rumià Arboix, Jordi
• dc.contributor.author Bulbena Vilarrasa, Antonio
• dc.contributor.author Pintor-Pérez, Luis
• dc.date.accessioned 2024-03-01T07:31:04Z
• dc.date.available 2024-03-01T07:31:04Z
• dc.date.issued 2023
• dc.description.abstract Objective: This study aims to assess the prevalence of Interictal Dysphoric Disorder (IDD) in drug-resistant epilepsy (DRE) and to describe its clinical and psychopathological profile, including personality, as well as its impact on quality of life (QOL). Method: A retrospective cross-sectional study from an Epilepsy Unit from January 2007 to December 2017. All patients were diagnosed with DRE. Patients underwent a battery of tests (HADS, SCL-90R, PDQ-4+, QOLIE-31) and a psychiatrist assessed the presence of Axis-I disorders and IDD. Statistical procedures were carried out using R-4.0.1 software. Results: A total of 282 patients were included. A statistically significant association was found between IDD and mood and anxiety disorders (p < 0.001 and p < 0.05 respectively), and between IDD and higher scores in all HADS and SCL-90-R items compared to subjects without IDD (p < 0.001). A statistically significant association was also found between IDD and obsessive-compulsive, borderline and depressive personality disorder (p < 0.05). Scores in all QOLIE-31 items except for 'medication effects' were significantly lower in subjects with IDD compared with subjects without IDD (p < 0.001). Conclusions: In DRE, IDD subjects show differences in the psychopathological profile and QOL scores compared to subjects without a diagnosis of IDD. An early diagnosis of IDD could facilitate prompt interventions which might positively impact QOL.
• dc.format.mimetype application/pdf
• dc.identifier.citation Monteagudo-Gimeno E, Sánchez-González R, Raduà-Castaño J, Fortea-González L, Boget-Llucià T, Carreño-Martínez M, Donaire-Pedraza A, Bargalló-Alabart N, Setoain-Perego X, Rumià-Arboix J, Bulbena-Vilarrasa A, Pintor-Pérez L. Clinical relevance of interictal dysphoric disorder and its impact on quality of life in drug-resistant epilepsy. Epilepsy Behav. 2023 Jul;144:109253. DOI: 10.1016/j.yebeh.2023.109253
• dc.identifier.doi http://dx.doi.org/10.1016/j.yebeh.2023.109253
• dc.identifier.issn 1525-5050
• dc.identifier.uri http://hdl.handle.net/10230/59300
• dc.language.iso eng
• dc.publisher Elsevier
• dc.relation.ispartof Epilepsy Behav. 2023 Jul;144:109253
• dc.rights © 2023 The Author(s). Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by/4.0/
• dc.subject.keyword Drug-Resistant Epilepsy
• dc.subject.keyword Interictal Dysphoric Disorder
• dc.subject.keyword Psychopathology
• dc.title Clinical relevance of interictal dysphoric disorder and its impact on quality of life in drug-resistant epilepsy
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion