Primate amygdala neurons simulate decision processes of social partners

Mostra el registre complet Registre parcial de l'ítem

• dc.contributor.author Grabenhorst, Fabian
• dc.contributor.author Báez-Mendoza, Raymundo
• dc.contributor.author Genest, Wilfried
• dc.contributor.author Deco, Gustavo
• dc.contributor.author Schultz, Wolfram
• dc.date.accessioned 2020-02-19T15:49:26Z
• dc.date.available 2020-02-19T15:49:26Z
• dc.date.issued 2019
• dc.description.abstract By observing their social partners, primates learn about reward values of objects. Here, we show that monkeys’ amygdala neurons derive object values from observation and use these values to simulate a partner monkey’s decision process. While monkeys alternated making reward-based choices, amygdala neurons encoded object-specific values learned from observation. Dynamic activities converted these values to representations of the recorded monkey’s own choices. Surprisingly, the same activity patterns unfolded spontaneously before partner’s choices in separate neurons, as if these neurons simulated the partner’s decision-making. These “simulation neurons” encoded signatures of mutual-inhibitory decision computation, including value comparisons and value-to-choice conversions, resulting in accurate predictions of partner’s choices. Population decoding identified differential contributions of amygdala subnuclei. Biophysical modeling of amygdala circuits showed that simulation neurons emerge naturally from convergence between object-value neurons and self-other neurons. By simulating decision computations during observation, these neurons could allow primates to reconstruct their social partners’ mental states.
• dc.description.sponsorship This work was supported by the Wellcome Trust (Principal Research Fellowship and Programme Grant 095495 to W.S.; Sir Henry Dale Fellowship 206207/Z/17/Z to F.G.), the European Research Council (ERC Advanced Grant 293549 to W.S.), the NIH Caltech Conte Center (P50MH094258 to W.S.), and the MGH ECOR Fund for Medical Discovery and NARSAD Young Investigator Grant from the Brain & Behavior Research Foundation (to R.B.-M.).
• dc.format.mimetype application/pdf
• dc.identifier.citation Grabenhorst F, Báez-Mendoza R, Genest W, Deco G, Schultz W. Primate amygdala neurons simulate decision drocesses of social partners. Cell. 2019 May 2;177(4):986-98. DOI: 10.1016/j.cell.2019.02.042
• dc.identifier.doi http://dx.doi.org/10.1016/j.cell.2019.02.042
• dc.identifier.issn 0092-8674
• dc.identifier.uri http://hdl.handle.net/10230/43658
• dc.language.iso eng
• dc.publisher Elsevier
• dc.relation.ispartof Cell. 2019 May 2;177(4):986-98
• dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/293549
• dc.rights This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by/4.0/
• dc.subject.keyword Reward
• dc.subject.keyword Decision-making
• dc.subject.keyword Observational learning
• dc.subject.keyword Social cognition
• dc.subject.keyword Mirror neuron
• dc.subject.keyword Autism
• dc.subject.keyword Theory of mind
• dc.subject.keyword Attractor network
• dc.title Primate amygdala neurons simulate decision processes of social partners
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion