Residential ambient air pollution exposure and the development of white matter microstructure throughout adolescence

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• dc.contributor.author Kusters, Michelle S.W.
• dc.contributor.author López Vicente, Mònica, 1988-
• dc.contributor.author Muetzel, Ryan L.
• dc.contributor.author Binter, Anne-Claire
• dc.contributor.author Petricola, Sami
• dc.contributor.author Tiemeier, Henning
• dc.contributor.author Guxens Junyent, Mònica
• dc.date.accessioned 2024-11-22T11:37:00Z
• dc.date.available 2024-11-22T11:37:00Z
• dc.date.issued 2024
• dc.description.abstract Background: Recent evidence suggests an association of air pollution exposure with brain development, but evidence on white matter microstructure in children is scarce. We investigated how air pollution exposure during pregnancy and childhood impacts longitudinal development of white matter microstructure throughout adolescence. Methods: Our study population consisted of 4108 participants of Generation R, a large population-based birth cohort from Rotterdam, the Netherlands. Residential air pollution exposure to 14 air pollutants during pregnancy and childhood was estimated with land-use regression models. Diffusion tensor images were obtained around age 10 and 14, resulting in a total of 5422 useable scans (n = 3082 for wave 1 and n = 2340 for wave 2; n = 1314 for participants with data on both waves). We calculated whole-brain fractional anisotropy (FA) and mean diffusivity (MD) and performed single- and multi-pollutant analyses using mixed effects models adjusted for life-style and socioeconomic status variables. Results: Higher exposure to PM2.5 during pregnancy, and PM10, PM2.5, PM2.5-10, and NOX during childhood was associated with a consistently lower whole-brain FA throughout adolescence (e.g. - 0.07 × 10-2 FA [95%CI -0.12; -0.02] per 1 standard deviation higher PM2.5 exposure during pregnancy). Higher exposure to silicon (Si) in PM2.5 and oxidative potential of PM2.5 during pregnancy, and PM2.5 during childhood was associated with an initial higher MD followed by a faster decrease in MD throughout adolescence (e.g. - 0.02 × 10-5 mm2/s MD [95%CI -0.03; -0.00] per year of age per 1 standard deviation higher Si exposure during pregnancy). Results were comparable when performing the analysis in children with complete data on the outcome for both neuroimaging assessments. Conclusions: Exposure to several pollutants was associated with a consistently lower whole-brain FA throughout adolescence. The association of few pollutants with whole-brain MD at baseline attenuated throughout adolescence. These findings suggest both persistent and age-limited associations of air pollution exposure with white matter microstructure.
• dc.description.sponsorship This publication was co-financed by the Agencia Estatal de Investigación (AEI) and the European Social Fund (FSE) " EL FSE invierte en tu futuro" with reference number PRE2020-092005, according to the Resolution of the Presidency of the AEI, by which grants are awarded for pre-doctoral contracts for the training of doctors, call 2020 (awarded to M.S.W.K). Neuroimaging data collection and analysis were supported by the Sophia Foundation project S18-20 (awarded to R.L.M.), the Netherlands Organization for Scientific Research (NWO, 2012.042, exacte wetenschap, Surf/Snellius, awarded to R.L.M) and the Netherlands Organization for Health Research and Development (ZonMw) Vici project 016.VICI.170.200 (awarded to H.T.). M.G. was funded by a Miguel Servet II fellowship (CPII18/00018) from the Spanish Institute of Health Carlos III. M.L.V. was funded by Project IJC2020-045355-I, funded by MCIN/AEI/10.13039/501100011033 and by the European Union NextGenerationEU/PRTR. The general design of Generation R Study is made possible by financial support from the Erasmus Medical Center, Rotterdam, the Erasmus University Rotterdam, ZonMw, The Netherlands Organization for Scientific Research (NWO), and the Ministry of Health, Welfare, and Sport. The geocodification of the addresses of the study participants and the air pollution estimations were done within the framework of a project funded by the Health Effects Institute (HEI) (Assistance Award No. R-82811201). This study received funding from the European Union's Horizon 2020 research and innovation program under grant agreement No 874583 (ATHLETE project). This publication reflects only the authors' view and the European Commission is not responsible for any use that may be made of the information it contains. We acknowledge support from the grant CEX2023-0001290-S funded by MCIN/AEI/10.13039/501100011033, support from the Generalitat de Catalunya through the CERCA Program, and from the Ministry of Research and Universities of the Government of Catalonia (2021 SGR 01564).
• dc.format.mimetype application/pdf
• dc.identifier.citation Kusters MSW, López-Vicente M, Muetzel RL, Binter AC, Petricola S, Tiemeier H, et al. Residential ambient air pollution exposure and the development of white matter microstructure throughout adolescence. Environ Res. 2024 Dec 1;262(Pt 2):119828. DOI: 10.1016/j.envres.2024.119828
• dc.identifier.doi http://dx.doi.org/10.1016/j.envres.2024.119828
• dc.identifier.issn 0013-9351
• dc.identifier.uri http://hdl.handle.net/10230/68785
• dc.language.iso eng
• dc.publisher Elsevier
• dc.relation.ispartof Environ Res. 2024 Dec 1;262(Pt 2):119828
• dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/874583
• dc.rights © 2024 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by-nc/4.0/
• dc.subject.keyword Air pollutants
• dc.subject.keyword Brain development
• dc.subject.keyword Cohort studies
• dc.subject.keyword Environmental pollution
• dc.subject.keyword Neuroimaging
• dc.subject.keyword White matter microstructure
• dc.title Residential ambient air pollution exposure and the development of white matter microstructure throughout adolescence
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion