Residential ambient air pollution exposure and the development of white matter microstructure throughout adolescence

Kusters, Michelle S.W.; López Vicente, Mònica, 1988-; Muetzel, Ryan L.; Binter, Anne-Claire; Petricola, Sami; Tiemeier, Henning; Guxens Junyent, Mònica

doi:http://dx.doi.org/10.1016/j.envres.2024.119828

Residential ambient air pollution exposure and the development of white matter microstructure throughout adolescence

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Kusters MSW, López-Vicente M, Muetzel RL, Binter AC, Petricola S, Tiemeier H, et al. Residential ambient air pollution exposure and the development of white matter microstructure throughout adolescence. Environ Res. 2024 Dec 1;262(Pt 2):119828. DOI: 10.1016/j.envres.2024.119828

Abstract

Background: Recent evidence suggests an association of air pollution exposure with brain development, but evidence on white matter microstructure in children is scarce. We investigated how air pollution exposure during pregnancy and childhood impacts longitudinal development of white matter microstructure throughout adolescence. Methods: Our study population consisted of 4108 participants of Generation R, a large population-based birth cohort from Rotterdam, the Netherlands. Residential air pollution exposure to 14 air pollutants during pregnancy and childhood was estimated with land-use regression models. Diffusion tensor images were obtained around age 10 and 14, resulting in a total of 5422 useable scans (n = 3082 for wave 1 and n = 2340 for wave 2; n = 1314 for participants with data on both waves). We calculated whole-brain fractional anisotropy (FA) and mean diffusivity (MD) and performed single- and multi-pollutant analyses using mixed effects models adjusted for life-style and socioeconomic status variables. Results: Higher exposure to PM2.5 during pregnancy, and PM10, PM2.5, PM2.5-10, and NOX during childhood was associated with a consistently lower whole-brain FA throughout adolescence (e.g. - 0.07 × 10-2 FA [95%CI -0.12; -0.02] per 1 standard deviation higher PM2.5 exposure during pregnancy). Higher exposure to silicon (Si) in PM2.5 and oxidative potential of PM2.5 during pregnancy, and PM2.5 during childhood was associated with an initial higher MD followed by a faster decrease in MD throughout adolescence (e.g. - 0.02 × 10-5 mm2/s MD [95%CI -0.03; -0.00] per year of age per 1 standard deviation higher Si exposure during pregnancy). Results were comparable when performing the analysis in children with complete data on the outcome for both neuroimaging assessments. Conclusions: Exposure to several pollutants was associated with a consistently lower whole-brain FA throughout adolescence. The association of few pollutants with whole-brain MD at baseline attenuated throughout adolescence. These findings suggest both persistent and age-limited associations of air pollution exposure with white matter microstructure.