Whole-brain dynamics differentiate among cisgender and transgender individuals

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• dc.contributor.author Uribe, Carme
• dc.contributor.author Escrichs, Anira
• dc.contributor.author De Filippi, Eleonora
• dc.contributor.author Sanz Perl, Yonatan
• dc.contributor.author Junque, Carme
• dc.contributor.author Gomez-Gil, Esther
• dc.contributor.author Kringelbach, Morten L.
• dc.contributor.author Guillamon, Antonio
• dc.contributor.author Deco, Gustavo
• dc.date.accessioned 2023-03-08T07:25:30Z
• dc.date.available 2023-03-08T07:25:30Z
• dc.date.issued 2022
• dc.description.abstract How the brain represents gender identity is largely unknown, but some neural differences have recently been discovered. We used an intrinsic ignition framework to investigate whether there are gender differences in the propagation of neural activity across the whole-brain and within resting-state networks. Studying 29 trans men and 17 trans women with gender incongruence, 22 cis women, and 19 cis men, we computed the capability of a given brain area in space to propagate activity to other areas (mean-ignition), and the variability across time for each brain area (node-metastability). We found that both measurements differentiated all groups across the whole brain. At the network level, we found that compared to the other groups, cis men showed higher mean-ignition of the dorsal attention network and node-metastability of the dorsal and ventral attention, executive control, and temporal parietal networks. We also found higher mean-ignition values in cis men than in cis women within the executive control network, but higher mean-ignition in cis women than cis men and trans men for the default mode. Node-metastability was higher in cis men than cis women in the somatomotor network, while both mean-ignition and node-metastability were higher for cis men than trans men in the limbic network. Finally, we computed correlations between these measurements and a body image satisfaction score. Trans men's dissatisfaction as well as cis men's and cis women's satisfaction toward their own body image were distinctively associated with specific networks in each group. Overall, the study of the whole-brain network dynamical complexity discriminates gender identity groups, functional dynamic approaches could help disentangle the complex nature of the gender dimension in the brain.
• dc.description.sponsorship H2020 Excellent Science, Grant/Award Number: 945539; H2020 Marie Skłodowska-Curie Actions, Grant/Award Number: 888692; Ministerio de Ciencia e Innovación, Grant/Award Numbers: PGC2018-094919-B-C21, PID2019-105772GB
• dc.format.mimetype application/pdf
• dc.identifier.citation Uribe C, Escrichs A, de Filippi E, Sanz-Perl Y, Junque C, Gomez-Gil E, Kringelbach ML, Guillamon A, Deco G. Whole-brain dynamics differentiate among cisgender and transgender individuals. Hum Brain Mapp. 2022;43(13):4103-15. DOI: 10.1002/hbm.25905
• dc.identifier.doi http://dx.doi.org/10.1002/hbm.25905
• dc.identifier.issn 1065-9471
• dc.identifier.uri http://hdl.handle.net/10230/56106
• dc.language.iso eng
• dc.publisher Wiley
• dc.relation.ispartof Human Brain Mapping. 2022;43(13):4103-15.
• dc.relation.isreferencedby https://doi.org/10.17632/hjmfrv6vmg.2
• dc.relation.isreferencedby https://doi.org/10.17632/rw2yhtpj96.3
• dc.relation.isreferencedby https://doi.org/10.17632/bgyzz94mz9.3
• dc.relation.isreferencedby https://doi.org/10.6084/m9.figshare.14622564
• dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/945539
• dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/888692
• dc.relation.projectID info:eu-repo/grantAgreement/ES/2PE/PGC2018-094919-B-C21
• dc.relation.projectID info:eu-repo/grantAgreement/ES/2PE/PID2019-105772GB
• dc.rights © 2022 The Authors. Human Brain Mapping published by Wiley Periodicals LLC. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivsLicense, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/4.0/
• dc.subject.keyword cisgender
• dc.subject.keyword dynamical complexity
• dc.subject.keyword ignition
• dc.subject.keyword sex/gender differences
• dc.subject.keyword transgender
• dc.subject.keyword whole-brain dynamics
• dc.title Whole-brain dynamics differentiate among cisgender and transgender individuals
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion