Effects of COVID-19 pandemic confinement in patients with cognitive impairment

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• dc.contributor.author Barguilla Arribas, Ainara
• dc.contributor.author Fernández-Lebrero, Aida
• dc.contributor.author Estragués-Gázquez, Isabel
• dc.contributor.author García-Escobar, Greta
• dc.contributor.author Navalpotro-Gómez, Irene
• dc.contributor.author Manero, Rosa María
• dc.contributor.author Puente-Periz, Víctor
• dc.contributor.author Roquer, Jaume
• dc.contributor.author Puig-Pijoan, Albert
• dc.date.accessioned 2021-07-01T06:54:45Z
• dc.date.available 2021-07-01T06:54:45Z
• dc.date.issued 2020
• dc.description.abstract Introduction: State of emergency caused by COVID-19 pandemic and subsequent lockdown hit Spain on 14th March 2020 and lasted until 21st June 2020. Social isolation measures were applied. Medical attention was focused on COVID-19. Primary and social care were mainly performed by telephone. This exceptional situation may affect especially vulnerable patients such as people living with dementia. Our aim was to describe the influence of restrictive measures on patients living with mild cognitive decline and dementia evaluating SARS-CoV2 infection, changes in routines, cognitive decline stage, neuropsychiatric symptoms, delirium, falls, caregiver stress, and access to sanitary care. Materials and Methods: We gathered MCI and dementia patients with clinical follow-up before and after confinement from DegMar registry (Hospital del Mar). A telephone ad-hoc questionnaire was administered. Global status was assessed using CDR scale. Changes in neuropsychiatric symptoms were assessed by Neuropsychiatric Inventory (NPI) and retrospective interview for pre-confinement base characteristics. Results: We contacted a total of 60 patients, age 75.4 years ± 5,192. 53.3% were women. Alzheimer's Disease (41.7%) and Mild Cognitive Impairment (25%) were the most prevalent diagnosis. Remaining cases included different dementia disorders. A total of 10% of patients had been diagnosed with SARS-CoV-2. During confinement 70% of patients abandoned previous daily activities, 60% had cognitive worsening reported by relatives/caretakers, 15% presented delirium episodes, and 13% suffered increased incidence of falls. Caregivers reported an increased burden in 41% cases and burnout in 11% cases. 16% reported difficulties accessing medical care, 33% received medical phone assistance, 20% needed emergency care and 21% had changes in psychopharmacological therapies. Neuropsychiatric profile globally worsened (p < 0.000), also in particular items like agitation (p = 0.003), depression (p < 0.000), anxiety (p < 0.000) and changes in appetite (p = 0.004). Conclusion: SARS-CoV2-related lockdown resulted in an important effect over social and cognitive spheres and worsening of neuropsychiatric traits in patients living with mild cognitive decline and dementia. Although the uncertainty regarding the evolution of the pandemic makes strategy difficult, we need to reach patients and caregivers and develop adequate strategies to reinforce and adapt social and health care.
• dc.format.mimetype application/pdf
• dc.identifier.citation Barguilla A, Fernández-Lebrero A, Estragués-Gázquez I, García-Escobar G, Navalpotro-Gómez I, Manero RM, et al. Effects of COVID-19 pandemic confinement in patients with cognitive impairment. Front Neurol. 2020 Nov 24; 11: 589901. DOI: 10.3389/fneur.2020.589901
• dc.identifier.doi http://dx.doi.org/10.3389/fneur.2020.589901
• dc.identifier.issn 1664-2295
• dc.identifier.uri http://hdl.handle.net/10230/48030
• dc.language.iso eng
• dc.publisher Frontiers
• dc.rights Copyright © 2020 Barguilla, Fernández-Lebrero, Estragués-Gázquez, García Escobar, Navalpotro-Gómez, Manero, Puente-Periz, Roquer and Puig-Pijoan. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) http://creativecommons.org/licenses/by/4.0/. The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by/4.0/
• dc.subject.keyword COVID- 19
• dc.subject.keyword SARS - CoV-2
• dc.subject.keyword Anxiety
• dc.subject.keyword Cognitive impairment
• dc.subject.keyword Dementia
• dc.subject.keyword Depression
• dc.subject.keyword Neuropsychiatric
• dc.title Effects of COVID-19 pandemic confinement in patients with cognitive impairment
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion