NF-κB-dependent and -independent (moonlighting) IκBα functions in differentiation and cancer
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- dc.contributor.author Espinosa Blay, Lluís
- dc.contributor.other Marruecos, Laura
- dc.date.accessioned 2022-05-20T06:49:15Z
- dc.date.available 2022-05-20T06:49:15Z
- dc.date.issued 2021
- dc.description.abstract IκBα is considered to play an almost exclusive role as inhibitor of the NF-κB signaling pathway. However, previous results have demonstrated that SUMOylation imposes a distinct subcellular distribution, regulation, NF-κB-binding affinity and function to the IκBα protein. In this review we discuss the main alterations of IκBα found in cancer and whether they are (most likely) associated with NF-κB-dependent or NF-κB-independent (moonlighting) activities of the protein.
- dc.format.mimetype application/pdf
- dc.identifier.citation Espinosa L, Marruecos L. NF-κB-dependent and -independent (moonlighting) IκBα functions in differentiation and càncer. Biomedicines. 2021 Sep 21; 9(9): 1278. DOI: 10.3390/biomedicines9091278
- dc.identifier.doi http://dx.doi.org/10.3390/biomedicines9091278
- dc.identifier.issn 2227-9059
- dc.identifier.uri http://hdl.handle.net/10230/53187
- dc.language.iso eng
- dc.publisher MDPI
- dc.rights Copyright © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.rights.uri http://creativecommons.org/licenses/by/4.0/
- dc.subject.keyword IκBα
- dc.subject.keyword NF-κB
- dc.subject.keyword SUMOylation
- dc.subject.keyword Cancer
- dc.title NF-κB-dependent and -independent (moonlighting) IκBα functions in differentiation and cancer
- dc.type info:eu-repo/semantics/article
- dc.type.version info:eu-repo/semantics/publishedVersion