NF-κB-dependent and -independent (moonlighting) IκBα functions in differentiation and cancer

Espinosa Blay, Lluís

doi:http://dx.doi.org/10.3390/biomedicines9091278

NF-κB-dependent and -independent (moonlighting) IκBα functions in differentiation and cancer

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Espinosa L, Marruecos L. NF-κB-dependent and -independent (moonlighting) IκBα functions in differentiation and càncer. Biomedicines. 2021 Sep 21; 9(9): 1278. DOI: 10.3390/biomedicines9091278

Abstract

IκBα is considered to play an almost exclusive role as inhibitor of the NF-κB signaling pathway. However, previous results have demonstrated that SUMOylation imposes a distinct subcellular distribution, regulation, NF-κB-binding affinity and function to the IκBα protein. In this review we discuss the main alterations of IκBα found in cancer and whether they are (most likely) associated with NF-κB-dependent or NF-κB-independent (moonlighting) activities of the protein.