First-in-human demonstration of floating EMG sensors and stimulators wirelessly powered and operated by volume conduction

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• dc.contributor.author Becerra Fajardo, Laura
• dc.contributor.author Minguillon, Jesus
• dc.contributor.author Krob, Marc Oliver
• dc.contributor.author Rodrigues, Camila
• dc.contributor.author González Sánchez, Miguel
• dc.contributor.author Megía-García, Álvaro
• dc.contributor.author Redondo Galán, Carolina
• dc.contributor.author Gutiérrez Henares, Francisco
• dc.contributor.author Comerma-Montells, Albert
• dc.contributor.author Del-Alma, Antonio J.
• dc.contributor.author Gil-Agudo, Ángel
• dc.contributor.author Grandas, Francisco
• dc.contributor.author Schneider-Ickert, Andreas
• dc.contributor.author Barroso, Filipe O.
• dc.contributor.author Ivorra Cano, Antoni, 1974-
• dc.date.accessioned 2024-01-29T17:49:00Z
• dc.date.available 2024-01-29T17:49:00Z
• dc.date.issued 2024
• dc.description.abstract Background: Recently we reported the design and evaluation of floating semi-implantable devices that receive power from and bidirectionally communicate with an external system using coupling by volume conduction. The approach, of which the semi-implantable devices are proof-of-concept prototypes, may overcome some limitations presented by existing neuroprostheses, especially those related to implant size and deployment, as the implants avoid bulky components and can be developed as threadlike devices. Here, it is reported the first-in-human acute demonstration of these devices for electromyography (EMG) sensing and electrical stimulation. Methods: A proof-of-concept device, consisting of implantable thin-film electrodes and a nonimplantable miniature electronic circuit connected to them, was deployed in the upper or lower limb of six healthy participants. Two external electrodes were strapped around the limb and were connected to the external system which delivered high frequency current bursts. Within these bursts, 13 commands were modulated to communicate with the implant. Results: Four devices were deployed in the biceps brachii and the gastrocnemius medialis muscles, and the external system was able to power and communicate with them. Limitations regarding insertion and communication speed are reported. Sensing and stimulation parameters were configured from the external system. In one participant, electrical stimulation and EMG acquisition assays were performed, demonstrating the feasibility of the approach to power and communicate with the floating device. Conclusions: This is the first-in-human demonstration of EMG sensors and electrical stimulators powered and operated by volume conduction. These proof-of-concept devices can be miniaturized using current microelectronic technologies, enabling fully implantable networked neuroprosthetics.
• dc.description.sponsorship This work has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No. 779982 (Project EXTEND - Bidirectional Hyper-Connected Neural System). CR has been also partially funded by CSIC Interdisciplinary Thematic Platform (PTI+) NEURO-AGINGl+ (PTI-NEURO-AGING+). FOB thanks the financial support from the Spanish MCIN/AEI/https://doi.org/10.13039/501100011033 and by the “European Union NextGenerationEU/PRTR” under Grant agreement IJC2020-044467-I. AI gratefully acknowledges the financial support by ICREA under the ICREA Academia programme.
• dc.format.mimetype application/pdf
• dc.identifier.citation Becerra-Fajardo L, Minguillon J, Krob MO, Rodrigues C, González-Sánchez M, Megía-García Á, et al. First-in-human demonstration of floating EMG sensors and stimulators wirelessly powered and operated by volume conduction. J Neuroeng Rehabil. 2024 Jan 3;21(1):4. DOI: 10.1186/s12984-023-01295-5
• dc.identifier.doi http://dx.doi.org/10.1186/s12984-023-01295-5
• dc.identifier.issn 1743-0003
• dc.identifier.uri http://hdl.handle.net/10230/58868
• dc.language.iso eng
• dc.publisher BioMed Central
• dc.relation.ispartof J Neuroeng Rehabil. 2024 Jan 3;21(1):4
• dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/779982
• dc.relation.projectID info:eu-repo/grantAgreement/ES/2PE/IJC2020-044467-I
• dc.rights © The Author(s) 2023. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by/4.0/
• dc.subject.keyword AIMDs
• dc.subject.keyword Bidirectional communications
• dc.subject.keyword Electrical stimulation
• dc.subject.keyword Electromyography
• dc.subject.keyword Human validation
• dc.subject.keyword Neuroprostheses
• dc.subject.keyword Semi-implantable devices
• dc.subject.keyword Sensor
• dc.subject.keyword Volume conduction
• dc.subject.keyword Wireless power transfer
• dc.title First-in-human demonstration of floating EMG sensors and stimulators wirelessly powered and operated by volume conduction
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion