Toward a clinical real time tissue ablation technology: combining electroporation and electrolysis (E2)

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• dc.contributor.author Guenther, Enric
• dc.contributor.author Klein, Nina
• dc.contributor.author Mikus, Paul
• dc.contributor.author Botea, Florin
• dc.contributor.author Pautov, Mihail
• dc.contributor.author Lugnani, Franco
• dc.contributor.author Macchioro, Matteo
• dc.contributor.author Popescu, Irinel
• dc.contributor.author Stehling, Michael Klaus
• dc.contributor.author Rubinsky, Boris
• dc.date.accessioned 2021-03-12T08:02:48Z
• dc.date.available 2021-03-12T08:02:48Z
• dc.date.issued 2020
• dc.description.abstract Background: Percutaneous image-guided tissue ablation (IGA) plays a growing role in the clinical management of solid malignancies. Electroporation is used for IGA in several modalities: irreversible electroporation (IRE), and reversible electroporation with chemotoxic drugs, called electrochemotherapy (ECT). It was shown that the combination of electrolysis and electroporation—E2—affords tissue ablation with greater efficiency, that is, lower voltages, lower energy and shorter procedure times than IRE and without the need for chemotoxic additives as in ECT. Methods: A new E2 waveform was designed that delivers optimal doses of electroporation and electrolysis in a single waveform. A series of experiments were performed in the liver of pigs to evaluate E2 in the context of clinical applications. The goal was to find initial parameter boundaries in terms of electrical field, pulse duration and charge as well as tissue behavior to enable real time tissue ablation of clinically relevant volumes. Results: Histological results show that a single several hundred millisecond long E2 waveform can ablate large volume of tissue at relatively low voltages while preserving the integrity of large blood vessels and lumen structures in the ablation zone without the use of chemotoxic drugs or paralyzing drugs during anesthesia. This could translate clinically into much shorter treatment times and ease of use compared to other techniques that are currently applied.
• dc.format.mimetype application/pdf
• dc.identifier.citation Guenther E, Klein N, Mikus P, Botea F, Pautov M, Lugnani F, Macchioro M, Popescu I, Stehling MK, Rubinsky B. Toward a clinical real time tissue ablation technology: combining electroporation and electrolysis (E2). PeerJ. 2020 Jan 20;8:e7985. DOI: 10.7717/peerj.7985
• dc.identifier.doi http://dx.doi.org/10.7717/peerj.7985
• dc.identifier.issn 2167-8359
• dc.identifier.uri http://hdl.handle.net/10230/46744
• dc.language.iso eng
• dc.publisher PeerJ
• dc.relation.ispartof PeerJ. 2020 Jan 20;8:e7985
• dc.rights CC © 2020 Gunther et al. Distributed under Creative Commons CC-BY 4.0 https://www.creativecommons.org/licenses/by/4.0/
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri https://www.creativecommons.org/licenses/by/4.0/
• dc.subject.keyword Electrolysis
• dc.subject.keyword Irreversible electroporation
• dc.subject.keyword Electro chemo theraphy
• dc.subject.keyword Image guided tissue ablation
• dc.subject.keyword Medtec
• dc.subject.keyword Cancer treatment
• dc.title Toward a clinical real time tissue ablation technology: combining electroporation and electrolysis (E2)
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion