Cortical folding alterations in fetuses with isolated non-severe ventriculomegaly

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• dc.contributor.author Benkarim, Oualid M.
• dc.contributor.author Hahner, Nadine
• dc.contributor.author Piella Fenoy, Gemma
• dc.contributor.author Gratacós Solsona, Eduard
• dc.contributor.author González Ballester, Miguel Ángel, 1973-
• dc.contributor.author Eixarch, Elisenda
• dc.contributor.author Sanromà, Gerard
• dc.date.accessioned 2019-03-05T15:43:46Z
• dc.date.available 2019-03-05T15:43:46Z
• dc.date.issued 2018
• dc.description.abstract Neuroimaging of brain diseases plays a crucial role in understanding brain abnormalities and early diagnosis. Of great importance is the study of brain abnormalities in utero and the assessment of deviations in case of mal-development. In this work, brain magnetic resonance images from 23 isolated non-severe ventriculomegaly (INSVM) fetuses and 25 healthy controls between 26 and 29 gestational weeks were used to identify INSVM-related cortical folding deviations from normative development. Since these alterations may reflect abnormal neurodevelopment, our working hypothesis is that markers of cortical folding can provide cues to improve theprediction of later neurodevelopmental problems in INSVM subjects. We analyzed the relationship of ventricular enlargement with cortical folding alterations in a regional basis using several curvature-based measures de-scribing the folding of each cortical region. Statistical analysis (global and hemispheric) and sparse linear regression approaches were then used to find the cortical regions whose folding is associated with ventricular dilation. Results from both approaches were in great accordance, showing a significant cortical folding decrease in the insula, posterior part of the temporal lobe and occipital lobe. Moreover, compared to the global analysis, stronger ipsilateral associations of ventricular enlargement with reduced cortical folding were encountered by the hemispheric analysis. Our findings confirm and extend previous studies by identifying various cortical regions and emphasizing ipsilateral effects of ventricular enlargement in altered folding. This suggests that INSVM is an indicator of altered cortical development, and moreover, cortical regions with reduced folding constitute potential prognostic biomarkers to be used in follow-up studies to decipher the outcome of INSVM fetuses.en
• dc.description.sponsorship This work was co-financed by the Marie Curie FP7-PEOPLE-2012-COFUND Action, Grant agreement no: 600387. This study was partly supported by Instituto de Salud Carlos III (PI16/00861) integrados en el Plan Nacional de I+D+I y cofinanciados por el ISCIII-Subdirección General de Evaluación y el Fondo Europeo de Desarrollo Regional (FEDER) “ Una manera de hacer Europa".en
• dc.format.mimetype application/pdf
• dc.identifier.citation Benkarim OM, Hahner N, Piella G, Gratacos E, González Ballester MA, Eixarch E, Sanroma G. Cortical folding alterations in fetuses with isolated non-severe ventriculomegaly. NeuroImage: Clinical. 2018 Jan 28;18:103-14. DOI: 10.1016/j.nicl.2018.01.006
• dc.identifier.doi http://dx.doi.org/10.1016/j.nicl.2018.01.006
• dc.identifier.issn 2213-1582
• dc.identifier.uri http://hdl.handle.net/10230/36743
• dc.language.iso eng
• dc.publisher Elsevier
• dc.relation.ispartof NeuroImage: Clinical. 2018 Jan 28;18:103-14.
• dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/600387
• dc.rights © 2018 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/BY-NC-ND/4.0/).
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/BY-NC-ND/4.0/
• dc.subject.keyword Fetal brainen
• dc.subject.keyword MRIen
• dc.subject.keyword Ventriculomegalyen
• dc.subject.keyword Cortical foldingen
• dc.subject.keyword Statistical analysisen
• dc.subject.keyword Lassoen
• dc.title Cortical folding alterations in fetuses with isolated non-severe ventriculomegaly
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion