The septal bulge—an early echocardiographic sign in hypertensive heart disease

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• dc.contributor.author Gaudron, Daniel
• dc.contributor.author Liu, Dan
• dc.contributor.author Scholz, Friederike
• dc.contributor.author Hu, Kai
• dc.contributor.author Florescum, Christiane
• dc.contributor.author Herrmann, Sebastian
• dc.contributor.author Bijnens, Bart
• dc.contributor.author Ertl, Georg
• dc.contributor.author Störk, Stefan
• dc.contributor.author Weidemann, Frank
• dc.date.accessioned 2024-01-15T12:24:21Z
• dc.date.available 2024-01-15T12:24:21Z
• dc.date.issued 2016
• dc.description.abstract Patients in the early stage of hypertensive heart disease tend to have normal echocardiographic findings. The aim of this study was to investigate whether pathology-specific echocardiographic morphologic and functional parameters can help to detect subclinical hypertensive heart disease. One hundred ten consecutive patients without a history and medication for arterial hypertension (AH) or other cardiac diseases were enrolled. Standard echocardiography and two-dimensional speckle-tracking-imaging analysis were performed. Resting blood pressure (BP) measurement, cycle ergometer test (CET), and 24-hour ambulatory BP monitoring (ABPM) were conducted. Patients were referred to “septal bulge (SB)” group (basal-septal wall thickness ≥2 mm thicker than mid-septal wall thickness) or “no-SB” group. Echocardiographic SB was found in 48 (43.6%) of 110 patients. In this SB group, 38 (79.2%) patients showed AH either by CET or ABPM. In contrast, in the no-SB group (n = 62), 59 (95.2%) patients had no positive test for AH by CET or ABPM. When AH was solely defined by resting BP, SB was a reasonable predictive sign for AH (sensitivity 73%, specificity 76%). However, when AH was confirmed by CET or ABPM the echocardiographic SB strongly predicted clinical AH (sensitivity 93%, specificity 86%). In addition, regional myocardial deformation of the basal-septum in SB group was significantly lower than in no-SB group (14 ± 4% vs. 17 ± 4%; P < .001). In conclusion, SB is a morphologic echocardiographic sign for early hypertensive heart disease. Sophisticated BP evaluation including resting BP, ABPM, and CET should be performed in all patients with an accidental finding of a SB in echocardiography.
• dc.format.mimetype application/pdf
• dc.identifier.citation Gaudron PD, Liu D, Scholz F, Hu K, Florescu C, Herrmann S, et al. The septal bulge—an early echocardiographic sign in hypertensive heart disease. Journal of the American Society of Hypertension. 2016 Jan;10(1):70-80. DOI: 10.1016/j.jash.2015.11.006
• dc.identifier.doi http://dx.doi.org/10.1016/j.jash.2015.11.006
• dc.identifier.issn 1933-1711
• dc.identifier.uri http://hdl.handle.net/10230/58692
• dc.language.iso eng
• dc.publisher Elsevier
• dc.relation.ispartof Journal of the American Society of Hypertension. 2016 Jan;10(1):70-80
• dc.rights Copyright © 2023 Elsevier B.V., its licensors, and contributors. All rights are reserved, including those for text and data mining, AI training, and similar technologies. For all open access content, the Creative Commons licensing terms apply.
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/4.0/
• dc.subject.keyword Septal bulge
• dc.subject.keyword Hypertension
• dc.subject.keyword Blood pressure monitoring
• dc.subject.keyword Echocardiography
• dc.subject.keyword Heart disease
• dc.title The septal bulge—an early echocardiographic sign in hypertensive heart disease
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion