In vivo assessment of corneal barrier function through non-invasive impedance measurements using a flexible probe
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- dc.contributor.author Guimerà, Antonca
- dc.contributor.author Illa, Xavica
- dc.contributor.author Traver, Estefaniaca
- dc.contributor.author Marchán, Sandraca
- dc.contributor.author Herrero, Carmenca
- dc.contributor.author Maldonado, Miguel Joséca
- dc.contributor.author Lagunas, Carmenca
- dc.contributor.author Ivorra Cano, Antoni, 1974-ca
- dc.contributor.author Villa, Rosaca
- dc.date.accessioned 2016-04-28T11:27:59Z
- dc.date.available 2016-04-28T11:27:59Z
- dc.date.issued 2013ca
- dc.description.abstract The cornea is a transparent structure composed of three layers: the epithelium, the stroma and the endothelium. To maintain its ransparency the stroma remains in a constant state of dehydration. Consequently, any ion flow disorder through the covering layers can compromise the barrier function and, therefore the corneal homeostasis. Since ionic permeability has a fundamental impact on the passive electrical properties of living tissues, in this work it is proposed and demonstrated a diagnosis method based on tetrapolar impedance measurements performed by electrodes placed on the corneal surface. The contribution of each cornea layer to the total measured impedance has been analysed over a frequency range. Following the obtained guidelines, a flexible probe with integrated electrodes has been developed and manufactured using SU-8 photoresin. The feasibility of the proposed method has been evaluated in vivo by monitoring corneal epithelium wound healing. Obtained impedance measurements have been compared with measurements of permeability to sodium fluorescein from different excised corneas. Successful results demonstrate the feasibility of this novel flexible sensor and its capability to quantify corneal permeability in vivo in a non-invasive way.en
- dc.format.mimetype application/pdfca
- dc.identifier.citation Guimera A, Illa X, Traver E, Marchan S, Herrero C, Lagunas C, Maldonado MJ, Ivorra A, Villa R. In vivo assessment of corneal barrier function through non-invasive impedance measurements using a flexible probe. J Phys Conf Ser. 2013;434:012072. doi:10.1088/1742-6596/434/1/012072ca
- dc.identifier.doi http://dx.doi.org/10.1088/1742-6596/434/1/012072
- dc.identifier.issn 1742-6588ca
- dc.identifier.uri http://hdl.handle.net/10230/26212
- dc.language.iso engca
- dc.publisher IOP Publishing Ltdca
- dc.relation.ispartof Journal of physics. Conference series. 2013;434:012072.
- dc.rights Published under licence in Journal of Physics: Conference Series by IOP Publishing Ltd. CC-BY Content from this work may be used under the terms of the Creative Commons Attribution 3.0 licence. Any further distribution of this work must maintain attribution to the author(s) and the title of the work, journal citation and DOI.ca
- dc.rights.accessRights info:eu-repo/semantics/openAccessca
- dc.rights.uri http://creativecommons.org/licenses/by/3.0
- dc.title In vivo assessment of corneal barrier function through non-invasive impedance measurements using a flexible probeca
- dc.type info:eu-repo/semantics/articleca
- dc.type.version info:eu-repo/semantics/publishedVersionca