Feed-forward information and zero-lag synchronization in the sensory thalamocortical circuit are modulated during stimulus perception

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• dc.contributor.author Tauste Campo, Adrià, 1982-
• dc.contributor.author Vázquez, Yuriria
• dc.contributor.author Álvarez, Manuel
• dc.contributor.author Zainos, Antonio
• dc.contributor.author Rossi-Pool, Román
• dc.contributor.author Deco, Gustavo
• dc.contributor.author Romo, Ranulfo
• dc.date.accessioned 2021-02-26T07:16:32Z
• dc.date.available 2021-02-26T07:16:32Z
• dc.date.issued 2019
• dc.description.abstract The direction of functional information flow in the sensory thalamocortical circuit may play a role in stimulus perception, but, surprisingly, this process is poorly understood. We addressed this problem by evaluating a directional information measure between simultaneously recorded neurons from somatosensory thalamus (ventral posterolateral nucleus, VPL) and somatosensory cortex (S1) sharing the same cutaneous receptive field while monkeys judged the presence or absence of a tactile stimulus. During stimulus presence, feed-forward information (VPL → S1) increased as a function of the stimulus amplitude, while pure feed-back information (S1 → VPL) was unaffected. In parallel, zero-lag interaction emerged with increasing stimulus amplitude, reflecting externally driven thalamocortical synchronization during stimulus processing. Furthermore, VPL → S1 information decreased during error trials. Also, VPL → S1 and zero-lag interaction decreased when monkeys were not required to report the stimulus presence. These findings provide evidence that both the direction of information flow and the instant synchronization in the sensory thalamocortical circuit play a role in stimulus perception.en
• dc.description.sponsorship This work was supported by Dirección General de Asuntos del Personal Académico de la Universidad Nacional Autónoma de México Grants PAPIIT- IN202716 and PAPIIT-IN210819, Consejo Nacional de Ciencia y Tecnología Grant 240892 (to R.R.), Spanish Research Project PSI2016-75688-P [Agencia Estatal de Investigación/Fondo Europeo de Desarrollo Regional (AEI/FEDER), European Union] (to G.D.), by the European Union’s Horizon 2020 Research and Innovation Programme under Grants 720270 [Human Brain Project Specific Grant Agreement 1 (HBP SGA1)] and 785907 (HBP SGA2) (to G.D.), and by the Catalan Agència de Gestió d’Ajuts Universitaris i de Recerca (AGAUR) Programme 2017 Suport als Grups de Recerca (SGR) 1545 (to G.D.). Y.V. was supported by a Pew Latin American Fellowship and a Charles H. Revson Biomedical Science Fellowship.
• dc.format.mimetype application/pdf
• dc.identifier.citation Tauste Campo A, Vázquez Y, Álvarez M, Zainos A, Rossi-Pool R, Deco G, Romo R. Feed-forward information and zero-lag synchronization in the sensory thalamocortical circuit are modulated during stimulus perception. Proc Natl Acad Sci USA. 2019 Mar 25;116(15):7513-22. DOI: 10.1073/pnas.1819095116
• dc.identifier.doi http://dx.doi.org/10.1073/pnas.1819095116
• dc.identifier.issn 0027-8424
• dc.identifier.uri http://hdl.handle.net/10230/46594
• dc.language.iso eng
• dc.publisher National Academy of Sciences
• dc.relation.ispartof Proceedings of the National Academy of Sciences of the United States of America. 2019 Mar 25;116(15):7513-22
• dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/720270
• dc.relation.projectID info:eu-repo/grantAgreement/ES/1PN/PSI2016-75688-P
• dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/785907
• dc.rights © National Academy of Sciences
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.subject.keyword Behaving monkeysen
• dc.subject.keyword Somatosensory thalamocortical circuiten
• dc.subject.keyword Tactile detection tasken
• dc.subject.keyword Simultaneous single-unit recordingsen
• dc.subject.keyword Directed information-theoretic measureen
• dc.title Feed-forward information and zero-lag synchronization in the sensory thalamocortical circuit are modulated during stimulus perceptionen
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/acceptedVersion