Loss of consciousness reduces the stability of brain hubs and the heterogeneity of brain dynamics

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• dc.contributor.author López-González, Ane, 1993-
• dc.contributor.author Panda, Rajanikant
• dc.contributor.author Ponce-Alvarez, Adrián
• dc.contributor.author Zamora-López, Gorka
• dc.contributor.author Escrichs, Anira
• dc.contributor.author Martial, Charlotte
• dc.contributor.author Thibaut, Aurore
• dc.contributor.author Gosseries, Olivia
• dc.contributor.author Kringelbach, Morten L.
• dc.contributor.author Annen, Jitka
• dc.contributor.author Laureys, Steven
• dc.contributor.author Deco, Gustavo
• dc.date.accessioned 2022-07-04T06:15:22Z
• dc.date.available 2022-07-04T06:15:22Z
• dc.date.issued 2021
• dc.description.abstract Low-level states of consciousness are characterized by disruptions of brain activity that sustain arousal and awareness. Yet, how structural, dynamical, local and network brain properties interplay in the different levels of consciousness is unknown. Here, we study fMRI brain dynamics from patients that suffered brain injuries leading to a disorder of consciousness and from healthy subjects undergoing propofol-induced sedation. We show that pathological and pharmacological low-level states of consciousness display less recurrent, less connected and more segregated synchronization patterns than conscious state. We use whole-brain models built upon healthy and injured structural connectivity to interpret these dynamical effects. We found that low-level states of consciousness were associated with reduced network interactions, together with more homogeneous and more structurally constrained local dynamics. Notably, these changes lead the structural hub regions to lose their stability during low-level states of consciousness, thus attenuating the differences between hubs and non-hubs brain dynamics.
• dc.description.sponsorship A.L.G. and G.D. were supported by Swiss National Science Foundation Sinergia grant no. 170873. A.P.A. and G.D. received funding from the FLAG-ERA JTC (PCI2018- 092891). G.D., S.L. and G.Z.L. received funding from the European Union’s Horizon 2020 Framework Programme for Research and Innovation under the Specific Grant Agreement No. 785907 (Human Brain Project SGA2) and No. 945539 (Human Brain Project SGA3). G.D. acknowledges the Spanish Ministry Project PSI2016-75688-P (AEI/ FEDER), the Catalan Research Group Support 2017 SGR 1545, and AWAKENING (PID2019-105772GB-I00, AEI FEDER EU) funded by the Spanish Ministry of Science, Innovation and Universities (MCIU), State Research Agency (AEI) and European Regional Development Funds (FEDER). The study was further supported by the University and University Hospital of Liège, the Belgian National Funds for Scientific Research (FRS-FNRS), the European Space Agency (ESA) and the Belgian Federal Science Policy Office (BELSPO) in the framework of the PRODEX Programme, “Fondazione Europea di Ricerca Biomedica”, the Bial Foundation, the Mind Science Foundation and the European Commission, the fund Generet, the King Baudouin Foundation, AstraZeneca foundation, and the DOCMA project [EU-H2020-MSCA-RISE-778234]. R.P. is research fellow, O.G. is research associate and S.L. is research director at F.R.S.- FNRS. M.L.K. is supported by the ERC Consolidator Grant: CAREGIVING (no. 615539), Center for Music in the Brain, funded by the Danish National Research Foundation (DNRF117), and Centre for Eudaimonia and Human Flourishing funded by the Pettit and Carlsberg Foundations
• dc.format.mimetype application/pdf
• dc.identifier.citation López-González A, Panda R, Ponce-Alvarez A, Zamora-López G, Escrichs A, Martial C, Thibaut A, Gosseries O, Kringelbach ML, Annen J, Laureys S, Deco G. Loss of consciousness reduces the stability of brain hubs and the heterogeneity of brain dynamics. Commun Biol. 2021;4:1037. DOI: 10.1038/s42003-021-02537-9
• dc.identifier.doi http://doi.org/10.1038/s42003-021-02537-9
• dc.identifier.issn 2399-3642
• dc.identifier.uri http://hdl.handle.net/10230/53658
• dc.language.iso eng
• dc.publisher Nature Research
• dc.relation.ispartof Communication Biology. 2021;4:1037.
• dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/785907
• dc.relation.projectID info:eu-repo/grantAgreement/ES/2PE/PCI2018-092891
• dc.relation.projectID info:eu-repo/grantAgreement/ES/2PE/PSI2016-75688-P
• dc.relation.projectID info:eu-repo/grantAgreement/ES/2PE/PID2019-105772GB-I00
• dc.rights © The Author(s) 2021 This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/ licenses/by/4.0/.
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by/4.0/
• dc.subject.keyword Consciousness
• dc.subject.keyword Dynamical systems
• dc.title Loss of consciousness reduces the stability of brain hubs and the heterogeneity of brain dynamics
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion