Stochastic cortical neurodynamics underlying the memory and cognitive changes in aging

Mostra el registre complet Registre parcial de l'ítem

• dc.contributor.author Rolls, Edmund Tca
• dc.contributor.author Deco, Gustavoca
• dc.date.accessioned 2016-06-16T08:41:32Z
• dc.date.available 2016-06-16T08:41:32Z
• dc.date.issued 2015ca
• dc.description.abstract The relatively random spiking times of individual neurons provide a source of noise in the brain. We show how this noise interacting with altered depth in the basins of attraction of networks involved in short-term memory, attention, and episodic memory provide an approach to understanding some of the cognitive changes in normal aging. The effects of the neurobiological changes in aging that are considered include reduced synaptic modification and maintenance during learning produced in part through reduced acetylcholine in normal aging, reduced dopamine which reduces NMDA-receptor mediated effects, reduced noradrenaline which increases cAMP and thus shunts excitatory synaptic inputs, and the effects of a reduction in acetylcholine in increasing spike frequency adaptation. Using integrate-and-fire simulations of an attractor network implementing memory recall and short-term memory, it is shown that all these changes associated with aging reduce the firing rates of the excitatory neurons, which in turn reduce the depth of the basins of attraction, resulting in a much decreased probability in maintaining in short-term memory what has been recalled from the attractor network. This stochastic dynamics approach opens up new ways to understand and potentially treat the effects of normal aging on memory and cognitive functions.
• dc.description.sponsorship This research was supported by the Oxford Centre for Computational Neuroscience, Oxford, UK. GD was supported by the ERC Advanced Grant: DYSTRUCTURE (n. 295129), and by the Spanish Research Project SAF2010-16085.
• dc.format.mimetype application/pdfca
• dc.identifier.citation Rolls ET, Deco G. Stochastic cortical neurodynamics underlying the memory and cognitive changes in aging. Neurobiol Learn Mem. 2015;118:150-61. DOI: 10.1016/j.nlm.2014.12.003ca
• dc.identifier.doi http://dx.doi.org/10.1016/j.nlm.2014.12.003
• dc.identifier.issn 1074-7427ca
• dc.identifier.uri http://hdl.handle.net/10230/26926
• dc.language.iso engca
• dc.publisher Elsevierca
• dc.relation.ispartof Neurobiology of learning and memory. 2015;118:150-61
• dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/295129ca
• dc.relation.projectID info:eu-repo/grantAgreement/ES/3PN/SAF2010-16085
• dc.rights © Elsevier http://dx.doi.org/10.1016/j.nlm.2014.12.003ca
• dc.rights.accessRights info:eu-repo/semantics/openAccessca
• dc.subject.keyword Aging
• dc.subject.keyword Cortical attractor networks
• dc.subject.keyword Memory
• dc.subject.keyword Acetylcholine
• dc.subject.keyword NMDA receptors
• dc.title Stochastic cortical neurodynamics underlying the memory and cognitive changes in agingca
• dc.type info:eu-repo/semantics/articleca
• dc.type.version info:eu-repo/semantics/acceptedVersionca