Discrepancies between multi-electrode LFP and CSD phase-patterns: A forward modeling study

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• dc.contributor.author Hindriks, Rikkertca
• dc.contributor.author Arsiwalla, Xerxes D.ca
• dc.contributor.author Panagiotaropoulos, Theofanis I.ca
• dc.contributor.author Besserve, Michelca
• dc.contributor.author Verschure, Paul F. M. J.ca
• dc.contributor.author Logothetis, Nikosca
• dc.contributor.author Deco, Gustavoca
• dc.date.accessioned 2016-07-15T07:53:17Z
• dc.date.available 2016-07-15T07:53:17Z
• dc.date.issued 2016ca
• dc.description.abstract Multi-electrode recordings of local field potentials (LFPs) provide the opportunity to investigate the spatiotemporal organization of neural activity on the scale of several millimeters. In particular, the phases of oscillatory LFPs allow studying the coordination of neural oscillations in time and space and to tie it to cognitive processing. Given the computational roles of LFP phases, it is important to know how they relate to the phases of the underlying current source densities (CSDs) that generate them. Although CSDs and LFPs are distinct physical quantities, they are often (implicitly) identified when interpreting experimental observations. That this identification is problematic is clear from the fact that LFP phases change when switching to different electrode montages, while the underlying CSD phases remain unchanged. In this study we use a volume-conductor model to characterize discrepancies between LFP and CSD phase-patterns, to identify the contributing factors, and to assess the effect of different electrode montages. Although we focus on cortical LFPs recorded with two-dimensional (Utah) arrays, our findings are also relevant for other electrode configurations. We found that the main factors that determine the discrepancy between CSD and LFP phase-patterns are the frequency of the neural oscillations and the extent to which the laminar CSD profile is balanced. Furthermore, the presence of laminar phase-differences in cortical oscillations, as commonly observed in experiments, precludes identifying LFP phases with those of the CSD oscillations at a given cortical depth. This observation potentially complicates the interpretation of spike-LFP coherence and spike-triggered LFP averages. With respect to reference strategies, we found that the average-reference montage leads to larger discrepancies between LFP and CSD phases as compared with the referential montage, while the Laplacian montage reduces these discrepancies. We therefore advice to conduct analysis of two-dimensional LFP recordings using the Laplacian montage.
• dc.description.sponsorship RH and GD were funded by the European Research Council (Advanced Grant DYSTRUCTURE No. 295129), the Spanish Research Project PSI2013-42091-P, the CONSOLIDER-INGENIO 2010 Program CSD2007-00012, and the FP7-ICT Brainscales (269921). XA and PV are supported by the European Research Council's CDAC project: “The Role of Consciousness in Adaptive Behavior: A Combined Empirical, Computational and Robot based Approach” (ERC-2013- ADG 341196).
• dc.format.mimetype application/pdfca
• dc.identifier.citation Hindriks R, Arsiwalla XD, Panagiotaropoulos T, Besserve M, Verschure PFMJ, Logothetis N, Deco G. Discrepancies between multi-electrode LFP and CSD phase-patterns: A forward modeling study. Front Neural Circuits. 2016;10:51. DOI: 10.3389/fncir.2016.00051ca
• dc.identifier.doi http://dx.doi.org/10.3389/fncir.2016.00051
• dc.identifier.issn 1662-5110ca
• dc.identifier.uri http://hdl.handle.net/10230/27057
• dc.language.iso engca
• dc.publisher Frontiersca
• dc.relation.ispartof Frontiers in Neural Circuits. 2016;10:51
• dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/295129ca
• dc.relation.projectID info:eu-repo/grantAgreement/ES/1PE/PSI2013-42091-P
• dc.relation.projectID info:eu-repo/grantAgreement/ES/2PN/CSD2007-00012
• dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/269921
• dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/341196
• dc.rights © 2016 Hindriks, Arsiwalla, Panagiotaropoulos, Besserve, Verschure, Logothetis and Deco. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.ca
• dc.rights.accessRights info:eu-repo/semantics/openAccessca
• dc.rights.uri http://creativecommons.org/licenses/by/4.0/
• dc.subject.keyword Volume conduction
• dc.subject.keyword Local field potential (LFP)
• dc.subject.keyword Traveling wave
• dc.subject.keyword Neural oscillations
• dc.subject.keyword Forward modeling
• dc.subject.keyword Current source density (CSD)
• dc.subject.keyword Phase-dynamics
• dc.title Discrepancies between multi-electrode LFP and CSD phase-patterns: A forward modeling studyca
• dc.type info:eu-repo/semantics/articleca
• dc.type.version info:eu-repo/semantics/publishedVersionca