Macroscopic quantities of collective brain activity during wakefulness and anesthesia

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• dc.contributor.author Ponce-Alvarez, Adrián
• dc.contributor.author Uhrig, Lynn
• dc.contributor.author Deco, Nikolas
• dc.contributor.author Signorelli, Camilo Miguel
• dc.contributor.author Kringelbach, Morten L.
• dc.contributor.author Jarraya, Béchir
• dc.contributor.author Deco, Gustavo
• dc.date.accessioned 2023-03-08T07:24:39Z
• dc.date.available 2023-03-08T07:24:39Z
• dc.date.issued 2022
• dc.description.abstract The study of states of arousal is key to understand the principles of consciousness. Yet, how different brain states emerge from the collective activity of brain regions remains unknown. Here, we studied the fMRI brain activity of monkeys during wakefulness and anesthesia-induced loss of consciousness. We showed that the coupling between each brain region and the rest of the cortex provides an efficient statistic to classify the two brain states. Based on this and other statistics, we estimated maximum entropy models to derive collective, macroscopic properties that quantify the system’s capabilities to produce work, to contain information, and to transmit it, which were all maximized in the awake state. The differences in these properties were consistent with a phase transition from critical dynamics in the awake state to supercritical dynamics in the anesthetized state. Moreover, information-theoretic measures identified those parameters that impacted the most the network dynamics. We found that changes in the state of consciousness primarily depended on changes in network couplings of insular, cingulate, and parietal cortices. Our findings suggest that the brain state transition underlying the loss of consciousness is predominantly driven by the uncoupling of specific brain regions from the rest of the network.
• dc.description.sponsorship A.P.A., B.J., and G.D. received funding from the FLAG-ERA JTC (PCI2018-092891). G.D. acknowledges funding from the European Union’s Horizon 2020 FET Flagship Human Brain Project under Grant Agreement 785907 HBP SGA1, SGA2, and SGA3, the Spanish Ministry Research Project PSI2016-75688-P (AEI/FEDER), the Catalan Research Group Support 2017 SGR 1545, and AWAKENING (PID2019-105772GB-I00, AEI FEDER EU) funded by the Spanish Ministry of Science, Innovation and Universities (MCIU), State Research Agency (AEI) and European Regional Development Funds (FEDER). M.L.K. is supported by the ERC Consolidator Grant: CAREGIVING (n. 615539), Center for Music in the Brain, funded by the Danish National Research Foundation (DNRF117), and Centre for Eudaimonia and Human Flourishing funded by the Pettit and Carlsberg Foundations. BJ received funding from Fondation Bettencourt-Schueller, Université Paris-Saclay (UVSQ), Fondation de France, Collège de France and from INSERM. CMS was supported by Comisión Nacional de Investigación Ciencia y Tecnología (CONICYT, currently ANID) through Programa Formacion de Capital Avanzado (PFCHA), Doctoral scholarship Becas Chile: CONICYT PFCHA/DOCTORADO BECAS CHILE/2016—72170507.
• dc.format.mimetype application/pdf
• dc.identifier.citation Ponce-Alvarez A, Uhrig L, Deco N, Signorelli CM, Kringelbach ML, Jarraya B, Deco G. Macroscopic quantities of collective brain activity during wakefulness and anesthesia. Cereb Cortex. 2022;32(2):298–311. DOI: 10.1093/cercor/bhab209
• dc.identifier.doi http://dx.doi.org/10.1093/cercor/bhab209
• dc.identifier.issn 1047-3211
• dc.identifier.uri http://hdl.handle.net/10230/56091
• dc.language.iso eng
• dc.publisher Oxford University Press
• dc.relation.ispartof Cerebral Cortex. 2022;32(2):298–311.
• dc.relation.isreferencedby https://academic.oup.com/cercor/article-lookup/doi/10.1093/cercor/bhab209#supplementary-data
• dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/785907
• dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/615539
• dc.relation.projectID info:eu-repo/grantAgreement/ES/1PE/PSI2016-75688-P
• dc.relation.projectID info:eu-repo/grantAgreement/ES/2PE/PID2019-105772GB-I00
• dc.rights © Oxford University Press. This is a pre-copyedited, author-produced version of an article accepted for publication in Cerebral Cortex following peer review. The version of record Ponce-Alvarez A, Uhrig L, Deco N, Signorelli CM, Kringelbach ML, Jarraya B, Deco G. Macroscopic quantities of collective brain activity during wakefulness and anesthesia. Cereb Cortex. 2022;32(2):298–311 is available online at: https://doi.org/10.1093/cercor/bhab209.
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.subject.keyword brain states
• dc.subject.keyword Collective activity
• dc.subject.keyword consciousness
• dc.subject.keyword fMR
• dc.subject.keyword Imaximum entropy models
• dc.subject.keyword phase transitions
• dc.title Macroscopic quantities of collective brain activity during wakefulness and anesthesia
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/acceptedVersion