Tumor growth delay by adjuvant alternating electric fields which appears non-thermally mediated
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- dc.contributor.author Castellví Fernández, Quimca
- dc.contributor.author Ginestà, Mireia M.ca
- dc.contributor.author Capellá, Gabrielca
- dc.contributor.author Ivorra Cano, Antoni, 1974-ca
- dc.date.accessioned 2016-04-28T11:27:52Z
- dc.date.available 2016-04-28T11:27:52Z
- dc.date.issued 2015ca
- dc.description.abstract Delivery of the so-called Tumor Treatment Fields (TTFields) has been proposed as a cancer/ntherapy. These are low magnitude alternating electric fields at frequencies from 100 to 300 kHz/nwhich are applied continuously in a non-invasive manner. Electric field delivery may produce an/nincrease in temperature which cannot be neglected. We hypothesized that the reported results/nobtained by applying TTFields in vivo could be due to heat rather than to electrical forces as/npreviously suggested. Here it is presented an in vivo study in which pancreatic tumors/nsubcutaneously implanted in nude mice were treated for a week either with mild hyperthermia/n(41°C) or with TTFields (6 V/cm, 150 kHz) and tumor growth was assessed. Although the TTFields/napplied singly did not produce any significant effect, the combination with chemotherapy did show/na delay in tumor growth in comparison to animals treated only with chemotherapy (median relative/nreduction = 47%). We conclude that concomitant chemotherapy and TTFields delivery show a/nbeneficial impact on pancreatic tumor growth. Contrary to our hypothesis, this impact is nonrelated/nwith the induced temperature increase.en
- dc.description.sponsorship This research was supported by project grants (AR00311 - MICINN-TEC2010-11182-E, SAF2012-/n33636, RTICCC RD12/0036/0031) from the Spanish government and in part by a Marie Curie grant/n(IRG 256376) from the European Commission and by the Generalitat de Catalunya (2009 SGR/n1356).en
- dc.format.mimetype application/pdfca
- dc.identifier.citation Castellví Q, Ginestà MM, Capellà G, Ivorra A. Tumor growth delay by adjuvant alternating electric fields which appears non-thermally mediated. Bioelectrochemistry. 2015;105:16-24. doi:10.1016/j.bioelechem.2015.04.006ca
- dc.identifier.doi http://dx.doi.org/10.1016/j.bioelechem.2015.04.006
- dc.identifier.issn 1567-5394ca
- dc.identifier.uri http://hdl.handle.net/10230/26210
- dc.language.iso engca
- dc.publisher Elsevierca
- dc.relation.ispartof Bioelectrochemistry. 2015;105:16-24.
- dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/256376
- dc.relation.projectID info:eu-repo/grantAgreement/ES/3PN/TEC2010-11182
- dc.rights © Elsevier http://dx.doi.org/10.1016/j.bioelechem.2015.04.006ca
- dc.rights.accessRights info:eu-repo/semantics/openAccessca
- dc.subject.keyword Alternating electric fielden
- dc.subject.keyword Hyperthermiaen
- dc.subject.keyword Chemotherapeutic adjuvanten
- dc.subject.keyword Pancreatic tumoren
- dc.subject.keyword TTFieldsen
- dc.title Tumor growth delay by adjuvant alternating electric fields which appears non-thermally mediatedca
- dc.type info:eu-repo/semantics/articleca
- dc.type.version info:eu-repo/semantics/acceptedVersionca