Volitional learning promotes theta phase coding in the human hippocampus
Mostra el registre complet Registre parcial de l'ítem
- dc.contributor.author Pacheco Estefan, Daniel
- dc.contributor.author Zucca, Riccardo
- dc.contributor.author Arsiwalla, Xerxes D.
- dc.contributor.author Principe, Alessandro
- dc.contributor.author Zhang, Hui
- dc.contributor.author Rocamora, Rodrigo
- dc.contributor.author Axmacher, Nikolai
- dc.contributor.author Verschure, Paul F. M. J.
- dc.date.accessioned 2023-03-06T07:30:18Z
- dc.date.available 2023-03-06T07:30:18Z
- dc.date.issued 2021
- dc.description.abstract Electrophysiological studies in rodents show that active navigation enhances hippocampal theta oscillations (4–12 Hz), providing a temporal framework for stimulus-related neural codes. Here we show that active learning promotes a similar phase coding regime in humans, although in a lower frequency range (3–8 Hz). We analyzed intracranial electroencephalography (iEEG) from epilepsy patients who studied images under either volitional or passive learning conditions. Active learning increased memory performance and hippocampal theta oscillations and promoted a more accurate reactivation of stimulus-specific information during memory retrieval. Representational signals were clustered to opposite phases of the theta cycle during encoding and retrieval. Critically, during active but not passive learning, the temporal structure of intracycle reactivations in theta reflected the semantic similarity of stimuli, segregating conceptually similar items into more distant theta phases. Taken together, these results demonstrate a multilayered mechanism by which active learning improves memory via a phylogenetically old phase coding scheme.
- dc.description.sponsorship This work has received funding from the Horizon2020-EU program under grant agreement of the project ReHyb, ID: 871767, and from the Virtual Brain Cloud project under the program H2020-EU, ID: 826421. N.A. received funding from Deutsche Forschungsgemeinschaft (German Research Foundation) Projektnummer 316803389–SFB 1280, as well as via Projektnummer 122679504–SFB 874.
- dc.format.mimetype application/pdf
- dc.identifier.citation Pacheco Estefan D, Zucca R, Arsiwalla X, Principe A, Zhang H, Rocamora R, Axmacher N, Verschure PFMJ. Volitional learning promotes theta phase coding in the human hippocampus. Proc Natl Acad Sci U S A. 2021;118(10):e2021238118. DOI: 10.1073/pnas.2021238118
- dc.identifier.doi http://dx.doi.org/10.1073/pnas.2021238118
- dc.identifier.issn 0027-8424
- dc.identifier.uri http://hdl.handle.net/10230/56048
- dc.language.iso eng
- dc.publisher National Academy of Sciences
- dc.relation.ispartof Proceedings of the National Academy of Sciences of the United States of America. 2021;118(10):e2021238118.
- dc.relation.isreferencedby https://osf.io/j582a/
- dc.relation.isreferencedby https://www.pnas.org/doi/suppl/10.1073/pnas.2021238118/suppl_file/pnas.2021238118.sapp.pdf
- dc.relation.isreferencedby https://www.pnas.org/doi/suppl/10.1073/pnas.2021238118/suppl_file/pnas.2021238118.sd01.xlsx
- dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/871767
- dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/826421
- dc.rights This open access article is distributed under Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0 (CC BY-NC-ND).
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/
- dc.subject.keyword active learning
- dc.subject.keyword intracranial EEG
- dc.subject.keyword theta oscillations
- dc.subject.keyword neural phase coding
- dc.subject.keyword hippocampus
- dc.title Volitional learning promotes theta phase coding in the human hippocampus
- dc.type info:eu-repo/semantics/article
- dc.type.version info:eu-repo/semantics/publishedVersion