Distance disintegration delineates the brain connectivity failure of Alzheimer's disease
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- dc.contributor.author Costumero, Víctor
- dc.contributor.author Uquillas, Federico d'Oleire
- dc.contributor.author Díez, Ibai
- dc.contributor.author Andorrà, Magí
- dc.contributor.author Basaia, Silvia
- dc.contributor.author Bueichekú, Elisenda
- dc.contributor.author Ortiz Terán, Laura
- dc.contributor.author Belloch, Vicente
- dc.contributor.author Escudero Torrella, Joaquin
- dc.contributor.author Ávila, César
- dc.contributor.author Sepulcre, Jorge
- dc.date.accessioned 2020-03-19T10:55:42Z
- dc.date.issued 2020
- dc.description.abstract Alzheimer's disease (AD) is associated with brain network dysfunction. Network-based investigations of brain connectivity have mainly focused on alterations in the strength of connectivity; however, the network breakdown in AD spectrum is a complex scenario in which multiple pathways of connectivity are affected. To integrate connectivity changes that occur under AD-related conditions, here we developed a novel metric that computes the connectivity distance between cortical regions at the voxel level (or nodes). We studied 114 individuals with mild cognitive impairment, 24 with AD, and 27 healthy controls. Results showed that areas of the default mode network, salience network, and frontoparietal network display a remarkable network separation, or greater connectivity distances, from the rest of the brain. Furthermore, this greater connectivity distance was associated with lower global cognition. Overall, the investigation of AD-related changes in paths and distances of connectivity provides a novel framework for characterizing subjects with cognitive impairment; a framework that integrates the overall network topology changes of the brain and avoids biases toward unreferenced connectivity effects.en
- dc.description.sponsorship This research was supported by a grant from the National Institutes of Health (NIH) (grant No. R01AG061445 and R01AG061811) (K23-EB019023 to J. Sepulcre).
- dc.format.mimetype application/pdf
- dc.identifier.citation Costumero V, Uquillas FdO, Díez I, Andorrà M, Basaia S, Bueichekú E, Ortiz-Terán L, Belloch V, Escudero Torrella J, Ávila C, Sepulcre J. Distance disintegration delineates the brain connectivity failure of Alzheimer's disease. Neurobiol Aging. 2019 Dec 14. DOI: 10.1016/j.neurobiolaging.2019.12.005
- dc.identifier.doi http://dx.doi.org/10.1016/j.neurobiolaging.2019.12.005
- dc.identifier.issn 0197-4580
- dc.identifier.uri http://hdl.handle.net/10230/43956
- dc.language.iso eng
- dc.publisher Elsevier
- dc.relation.ispartof Neurobiology of Aging. 2019 Dec 14
- dc.rights © Elsevier http://dx.doi.org/10.1016/j.neurobiolaging.2019.12.005
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.subject.keyword Alzheimer's diseaseen
- dc.subject.keyword Mild Cognitive impairmenten
- dc.subject.keyword Functional connectivityen
- dc.subject.keyword Graph-theoryen
- dc.subject.keyword Stepwise connectivityen
- dc.subject.keyword Optimal distanceen
- dc.title Distance disintegration delineates the brain connectivity failure of Alzheimer's diseaseen
- dc.type info:eu-repo/semantics/article
- dc.type.version info:eu-repo/semantics/acceptedVersion