Synthetically programmed antioxidant delivery by a domesticated skin commensal
Synthetically programmed antioxidant delivery by a domesticated skin commensal
Citació
- Nevot G, Santos-Moreno J, Campamà-Sanz N, Toloza L, Parra-Cid C, Jansen PAM, et al. Synthetically programmed antioxidant delivery by a domesticated skin commensal. Cell Syst. 2025 Feb 19;16(2):101169. DOI: 10.1016/j.cels.2025.101169
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Descripció
Resum
Bacteria represent a promising dynamic delivery system for the treatment of disease. In the skin, the relevant location of Cutibacterium acnes within the hair follicle makes this bacterium an attractive chassis for dermal biotechnological applications. Here, we provide a genetic toolbox for the engineering of this traditionally intractable bacterium, including basic gene expression tools, biocontainment strategies, markerless genetic engineering, and dynamic transcriptional regulation. As a proof of concept, we develop an antioxidant-secreting strain capable of reducing oxidative stress in a UV stress model.