Dietary consumption of Type 2 resistant starch and d-fagomine delays progression of metabolic disturbances in male rats on high-fat diet

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• dc.contributor.author Miralles-Pérez, Bernat
• dc.contributor.author Ramos-Romero, Sara
• dc.contributor.author Charpentier, María José
• dc.contributor.author Sánchez-Martos, Vanessa
• dc.contributor.author Fortuño-Mar, Àngels
• dc.contributor.author Ponomarenko, Julia
• dc.contributor.author Amézqueta, Susana
• dc.contributor.author Piñol-Piñol, David
• dc.contributor.author Zhang, Xiang
• dc.contributor.author Torres, Josep Lluís
• dc.contributor.author Romeu, Marta
• dc.date.accessioned 2025-10-14T05:36:15Z
• dc.date.available 2025-10-14T05:36:15Z
• dc.date.issued 2025
• dc.description Data de publicació electrònica: 09-09-2025
• dc.description.abstract High-fat (HF) diets contribute to obesity, insulin resistance, fatty liver, gut microbiota dysbiosis, oxidative stress, and low-grade chronic inflammation. This study evaluated the preventive effects of dietary Type 2 resistant starch (RS2) from high-amylose maize and low-dose d-fagomine (FG) from buckwheat on these metabolic disturbances. Male Wistar-Kyoto rats (9-10 weeks old) were assigned to four diet groups for 10 weeks: standard (STD) diet, HF diet (45% kcal from fat), HF + RS diet (15% RS2), and HF + FG diet (0.1% FG). Body characteristics, metabolic parameters, oxidative stress, gut microbiota, short-chain fatty acids (SCFAs), and eicosanoids were analyzed. Both HF + RS and HF + FG diets reduced perigonadal fat, plasma triacylglycerols, and oxidative stress. HF + RS diet improved glucose tolerance without significantly affecting insulin sensitivity, while HF + FG diet showed a tendency for improvement at later stages. Additionally, HF + RS diet showed greater beneficial effects on body weight and liver steatosis than HF + FG diet, likely due to gut microbiota and SCFA modulation. RS2 exerted stronger metabolic effects than FG under HF diet conditions, suggesting its greater potential in mitigating obesity-related complications. FG effects may require longer exposure to manifest.
• dc.format.mimetype application/pdf
• dc.identifier.citation Miralles-Pérez B, Ramos-Romero S, Charpentier MJ, Sánchez-Martos V, Fortuño-Mar À, Ponomarenko J, et al. Dietary consumption of Type 2 resistant starch and d-fagomine delays progression of metabolic disturbances in male rats on high-fat diet. Mol Nutr Food Res. 2025 Sep 9:e70230. DOI: 10.1002/mnfr.70230
• dc.identifier.doi http://dx.doi.org/10.1002/mnfr.70230
• dc.identifier.issn 1613-4125
• dc.identifier.uri http://hdl.handle.net/10230/71494
• dc.language.iso eng
• dc.publisher Wiley
• dc.relation.ispartof Molecular nutrition & food research. 2025 Sep 9:e70230
• dc.rights © 2025 The Author(s). Molecular Nutrition & Food Research published by Wiley-VCH GmbH. This is an open access article under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by/4.0/
• dc.subject.keyword Atherogenic dyslipidemia
• dc.subject.keyword Fiber
• dc.subject.keyword Iminosugar
• dc.subject.keyword Oxidative stress
• dc.subject.keyword Prediabetes
• dc.title Dietary consumption of Type 2 resistant starch and d-fagomine delays progression of metabolic disturbances in male rats on high-fat diet
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion