Increased brain atrophy and lesion load is associated with stronger lower alpha MEG power in multiple sclerosis patients

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• dc.contributor.author Van Schependom, Jeroen
• dc.contributor.author Vidaurre, Diego
• dc.contributor.author Costers, Lars
• dc.contributor.author Sjøgård, Martin
• dc.contributor.author Sima, Diana M.
• dc.contributor.author Smeets, Dirk
• dc.contributor.author D'hooghe, Marie Beatrice
• dc.contributor.author D'haeseleer, Miguel
• dc.contributor.author Deco, Gustavo
• dc.contributor.author Wens, Vincent
• dc.contributor.author De Tiège, Xavier
• dc.contributor.author Goldman, Serge
• dc.contributor.author Woolrich, Mark W.
• dc.contributor.author Nagels, Guy
• dc.date.accessioned 2021-05-06T10:20:07Z
• dc.date.available 2021-05-06T10:20:07Z
• dc.date.issued 2021
• dc.description.abstract In multiple sclerosis, the interplay of neurodegeneration, demyelination and inflammation leads to changes in neurophysiological functioning. This study aims to characterize the relation between reduced brain volumes and spectral power in multiple sclerosis patients and matched healthy subjects. During resting-state eyes closed, we collected magnetoencephalographic data in 67 multiple sclerosis patients and 47 healthy subjects, matched for age and gender. Additionally, we quantified different brain volumes through magnetic resonance imaging (MRI). First, a principal component analysis of MRI-derived brain volumes demonstrates that atrophy can be largely described by two components: one overall degenerative component that correlates strongly with different cognitive tests, and one component that mainly captures degeneration of the cortical grey matter that strongly correlates with age. A multimodal correlation analysis indicates that increased brain atrophy and lesion load is accompanied by increased spectral power in the lower alpha (8–10 Hz) in the temporoparietal junction (TPJ). Increased lower alpha power in the TPJ was further associated with worse results on verbal and spatial working memory tests, whereas an increased lower/upper alpha power ratio was associated with slower information processing speed. In conclusion, multiple sclerosis patients with increased brain atrophy, lesion and thalamic volumes demonstrated increased lower alpha power in the TPJ and reduced cognitive abilities.
• dc.description.sponsorship JVS is funded by an FWO post-doc grant (12I1817N, www.fwo.be). LC is funded by an FWO aspirant grant (11B7218N) and GN is supported by an FWO “Fundamenteel klinisch mandaat” (1805620 N). Martin Sjøgård was supported by the Wiener-Anspach Foundation (Brussels, Belgium and Oxford, UK) and is supported by the “Marc Errens” Research Convention of the Fonds Erasme (Fonds Erasme, Brussels, Belgium). Xavier De Tiège is Postdoctorate Clinical Master Specialist at the Fonds de la Recherche Scientifique (FRS-FNRS, Brussels, Belgium). Data collection was enabled by a grant provided by the Belgian Charcot foundation awarded on Jan 16, 2015, by an FWO “Krediet aan Navorser” grant (1501218 N, www.fwo.be) granted to JVS, by an unrestricted researcher initiated grant provided by Genzyme-Sanofi to GN, and by the “Marc Errens” Research Convention of the Fonds Erasme (Fonds Erasme, Brussels, Belgium). The MEG project at the CUB – Hôpital Erasme is financially supported by the Fonds Erasme pour la Recherche Médicale (Research Convention “Les Voies du Savoir”, Brussels, Belgium). DV is supported by a Novonordisk Hallas-Møller Emerging Investigator Award (0054895), and a Horizon 2020 ERC Starting Grant (850404). The publication was supported by the Belgian Universitary Foundation (Universitaire Stichting).
• dc.format.mimetype application/pdf
• dc.identifier.citation Van Schependom J, Vidaurre D, Costers L, Sjøgård M, Sima DM, Smeets D, D'hooghe MB, D'haeseleer M, Deco G, Wens V, De Tiège X, Goldman S, Woolrich M, Nagels G. Increased brain atrophy and lesion load is associated with stronger lower alpha MEG power in multiple sclerosis patients. Neuroimage Clin. 2021;30:102632. DOI: 10.1016/j.nicl.2021.102632
• dc.identifier.doi http://dx.doi.org/10.1016/j.nicl.2021.102632
• dc.identifier.issn 2213-1582
• dc.identifier.uri http://hdl.handle.net/10230/47342
• dc.language.iso eng
• dc.publisher Elsevier
• dc.relation.ispartof Neuroimage Clinical. 2021;30:102632
• dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/850404
• dc.rights © 2021 The Author(s). Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license https://creativecommons.org/licenses/by-nc-nd/4.0/
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/
• dc.subject.keyword Multiple sclerosis
• dc.subject.keyword Structural neuroimaging
• dc.subject.keyword Magnetoencephalography
• dc.subject.keyword Resting state
• dc.subject.keyword Spectral power
• dc.title Increased brain atrophy and lesion load is associated with stronger lower alpha MEG power in multiple sclerosis patients
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion