A dynamical systems hypothesis of schizophrenia

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• dc.contributor.author Loh, Marco
• dc.contributor.author Rolls, Edmund T
• dc.contributor.author Deco, Gustavo
• dc.date.accessioned 2021-03-09T10:28:08Z
• dc.date.available 2021-03-09T10:28:08Z
• dc.date.issued 2007
• dc.description.abstract We propose a top-down approach to the symptoms of schizophrenia based on a statistical dynamical framework. We show that a reduced depth in the basins of attraction of cortical attractor states destabilizes the activity at the network level due to the constant statistical fluctuations caused by the stochastic spiking of neurons. In integrate-and-fire network simulations, a decrease in the NMDA receptor conductances, which reduces the depth of the attractor basins, decreases the stability of short-term memory states and increases distractibility. The cognitive symptoms of schizophrenia such as distractibility, working memory deficits, or poor attention could be caused by this instability of attractor states in prefrontal cortical networks. Lower firing rates are also produced, and in the orbitofrontal and anterior cingulate cortex could account for the negative symptoms, including a reduction of emotions. Decreasing the GABA as well as the NMDA conductances produces not only switches between the attractor states, but also jumps from spontaneous activity into one of the attractors. We relate this to the positive symptoms of schizophrenia, including delusions, paranoia, and hallucinations, which may arise because the basins of attraction are shallow and there is instability in temporal lobe semantic memory networks, leading thoughts to move too freely round the attractor energy landscape.
• dc.description.sponsorship ML was supported by the Boehringer Ingelheim Fonds. Support was also provided by the Oxford McDonnell Centre for Cognitive Neuroscience
• dc.format.mimetype application/pdf
• dc.identifier.citation Loh M, Rolls ET, Deco G. A dynamical systems hypothesis of schizophrenia. PLoS Comput Biol. 2007 Nov;3(11):e228. DOI: 10.1371/journal.pcbi.0030228
• dc.identifier.doi http://dx.doi.org/10.1371/journal.pcbi.0030228
• dc.identifier.issn 1553-734X
• dc.identifier.uri http://hdl.handle.net/10230/46700
• dc.language.iso eng
• dc.publisher Public Library of Science (PLoS)
• dc.relation.ispartof PLoS Comput Biol. 2007 Nov;3(11):e228
• dc.rights © 2007 Loh et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.subject.keyword Receptors, GABA
• dc.subject.keyword Receptors, N-Methyl-D-Aspartate
• dc.subject.keyword Schizophrenia
• dc.subject.keyword Synaptic Transmission
• dc.title A dynamical systems hypothesis of schizophrenia
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion