Influence of gender on right ventricle adaptation to endurance exercise: an ultrasound two-dimensional speckle-tracking stress study

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• dc.contributor.author Sanz de la Garza, Maria
• dc.contributor.author Giraldeau, Geneviève
• dc.contributor.author Marin, Josefa
• dc.contributor.author Grazioli, Gonzalo
• dc.contributor.author Esteve, Montserrat
• dc.contributor.author Gabrielli, Luigi
• dc.contributor.author Brambila, Carlos
• dc.contributor.author Sanchis, Laura
• dc.contributor.author Bijnens, Bart
• dc.contributor.author Sitges, Marta
• dc.date.accessioned 2019-03-28T11:07:44Z
• dc.date.available 2019-03-28T11:07:44Z
• dc.date.issued 2017
• dc.description.abstract Background: Characteristic right ventricle (RV) remodelling is related to endurance exercise in male athletes (MAs), but data in female athletes (FAs) are scarce. Our aim was to evaluate sex-related influence on exercise-induced RV remodelling and on RV performance during exercise. Methods: Forty endurance athletes (>10 training hours/week, 50% female) and 40 age-matched controls (<3 h moderate exercise/week, 50% female) were included. Echocardiography was performed at rest and at maximum cycle-ergometer effort. Both ventricles were analysed by standard and speckle-tracking echocardiography. Results: Endurance training induced similar structural and functional cardiac remodelling in MAs and FAs, characterized by bi-ventricular dilatation [~34%, left ventricle (LV); 29%, RV] and normal bi-ventricular function. However, males had larger RV size (p < 0.01), compared to females: RV end-diastolic area (cm2/m2): 15.6 ± 2.2 vs 11.6 ± 1.7 in athletes; 12.2 ± 2.7 vs 8.6 ± 1.6 in controls, respectively, and lower bi-ventricular deformation (RV global longitudinal strain (GLS) (%): −24.0 ± 3.6 vs −29.2 ± 3.1 in athletes; −24.9 ± 2.5 vs −30.0 ± 1.9 in controls, and LVGLS: −17.5 ± 1.4 vs −21.9 ± 1.9 in athletes; −18.7 ± 1.2 vs −22.5 ± 1.5 in controls, respectively, p < 0.01). During exercise, the increase in LV function was positively correlated (p < 0.01) with increased cardiac output (∆%LV ejection fraction, r = +0.46 and ∆%LVGLS, r = +0.36). Improvement in RV performance was blunted at high workloads, especially in MAs. Conclusion: Long-term endurance training induced similar bi-ventricular remodelling in MAs and FAs. Independently of training load, males had larger RV size and lower bi-ventricular deformation. Improvement in RV performance during exercise was blunted at high workloads, especially in MAs. The potential mechanisms underlying these findings warrant further investigation.
• dc.description.sponsorship This work was partially funded by grants from the Generalitat de Catalunya FI-AGAUR 2014–2017 (RH 040991, M. Sanz), and from the Spanish Government (Plan Nacional I + D, Ministerio de Economia y Competitividad DEP2013-44923-P; TIN2014-52923-R and FEDER).
• dc.format.mimetype application/pdf
• dc.identifier.citation Sanz-de la Garza M, Giraldeau G, Marin J, Grazioli G, Esteve M, Gabrielli L, Brambila C, Sanchis L, Bijnens B, Sitges M. Influence of gender on right ventricle adaptation to endurance exercise: an ultrasound two-dimensional speckle-tracking stress study. Eur J Appl Physiol. 2017 Mar;117(3):389-96. DOI: 10.1007/s00421-017-3546-8
• dc.identifier.doi http://dx.doi.org/10.1007/s00421-017-3546-8
• dc.identifier.issn 1439-6319
• dc.identifier.uri http://hdl.handle.net/10230/37003
• dc.language.iso eng
• dc.publisher Springer
• dc.relation.ispartof European Journal of Applied Physiology. 2017 Mar;117(3):389-96.
• dc.relation.projectID info:eu-repo/grantAgreement/ES/1PE/DEP2013-44923-P
• dc.relation.projectID info:eu-repo/grantAgreement/ES/1PE/TIN2014-52923-R
• dc.rights © Springer The final publication is available at Springer via http://dx.doi.org/10.1007/s00421-017-3546-8
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.subject.keyword Athlete’s heart
• dc.subject.keyword Sex
• dc.subject.keyword Exercise
• dc.subject.keyword Endurance training
• dc.subject.keyword Right ventricle
• dc.title Influence of gender on right ventricle adaptation to endurance exercise: an ultrasound two-dimensional speckle-tracking stress study
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/acceptedVersion