Motor adaptation impairment in chronic cannabis users assessed by a visuomotor rotation task
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- dc.contributor.author Herreros Alonso, Ivan
- dc.contributor.author Miquel, Laia
- dc.contributor.author Blithikioti, Chrysanthi
- dc.contributor.author Nuño, Laura
- dc.contributor.author Rubio Ballester, Belén
- dc.contributor.author Grechuta, Klaudia
- dc.contributor.author Gual, Antoni
- dc.contributor.author Balcells-Oliveró, Mercè
- dc.contributor.author Verschure, Paul F. M. J.
- dc.date.accessioned 2023-01-24T07:14:31Z
- dc.date.available 2023-01-24T07:14:31Z
- dc.date.issued 2019
- dc.description.abstract Background—The cerebellum has been recently suggested as an important player in the addiction brain circuit. Cannabis is one of the most used drugs worldwide, and its long-term effects on the central nervous system are not fully understood. No valid clinical evaluations of cannabis impact on the brain are available today. The cerebellum is expected to be one of the brain structures that are highly affected by prolonged exposure to cannabis, due to its high density in endocannabinoid receptors. We aim to use a motor adaptation paradigm to indirectly assess cerebellar function in chronic cannabis users (CCUs). Methods—We used a visuomotor rotation (VMR) task that probes a putatively-cerebellar implicit motor adaptation process together with the learning and execution of an explicit aiming rule. We conducted a case-control study, recruiting 18 CCUs and 18 age-matched healthy controls. Our main measure was the angular aiming error. Results—Our results show that CCUs have impaired implicit motor adaptation, as they showed a smaller rate of adaptation compared with healthy controls (drift rate: 19.3 +/− 6.8° vs. 27.4 +/− 11.6°; t(26) = −2.1, p = 0.048, Cohen’s d = −0.8, 95% CI = (−1.7, −0.15)). Conclusions—We suggest that a visuomotor rotation task might be the first step towards developing a useful tool for the detection of alterations in implicit learning among cannabis users.
- dc.description.sponsorship This work was supported by MINECO “Retos Investigacion I+d+i”, Plan Nacional project, SANAR (Gobierno de España)—under agreement TIN2013-44200-REC, FPI grant nr. BES-2014-068791, and by the European Research Council under grant agreement 341196 (CDAC).
- dc.format.mimetype application/pdf
- dc.identifier.citation Herreros I, Miquel L, Blithikioti C, Nuño L, Rubio B, Grechuta K, et al. Motor adaptation impairment in chronic cannabis users assessed by a visuomotor rotation task. J Clin Med. 2019 Jul;8(7):1049. DOI: 10.3390/jcm8071049
- dc.identifier.doi http://dx.doi.org/10.3390/jcm8071049
- dc.identifier.issn 2077-0383
- dc.identifier.uri http://hdl.handle.net/10230/55401
- dc.language.iso eng
- dc.publisher MDPI
- dc.relation.ispartof Journal of Clinical Medicine. 2019 Jul;8(7):1049
- dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/341196
- dc.relation.projectID info:eu-repo/grantAgreement/ES/1PE/TIN2013-44200-REC
- dc.relation.projectID info:eu-repo/grantAgreement/ES/1PE/BES-2014-068791
- dc.rights © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.rights.uri http://creativecommons.org/licenses/by/4.0/
- dc.subject.keyword Cerebellum
- dc.subject.keyword Cannabis
- dc.subject.keyword Implicit motor learning
- dc.subject.keyword Motor adaptation
- dc.subject.keyword Visuomotor rotation
- dc.title Motor adaptation impairment in chronic cannabis users assessed by a visuomotor rotation task
- dc.type info:eu-repo/semantics/article
- dc.type.version info:eu-repo/semantics/publishedVersion