Whole-brain analyses indicate the impairment of posterior integration and thalamo-frontotemporal broadcasting in disorders of consciousness

Panda, Rajanikant; López-González, Ane, 1993-; Gilson, Matthieu; Gosseries, Olivia; Thibaut, Aurore; Frasso, Gianluca; Cecconi, Benedetta; Escrichs, Anira; Coma Science Group Collaborators; Deco, Gustavo; Laureys, Steven; Zamora-López, Gorka; Annen, Jitka

Whole-brain analyses indicate the impairment of posterior integration and thalamo-frontotemporal broadcasting in disorders of consciousness

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dc.contributor.author Panda, Rajanikant
dc.contributor.author López-González, Ane, 1993-
dc.contributor.author Gilson, Matthieu
dc.contributor.author Gosseries, Olivia
dc.contributor.author Thibaut, Aurore
dc.contributor.author Frasso, Gianluca
dc.contributor.author Cecconi, Benedetta
dc.contributor.author Escrichs, Anira
dc.contributor.author Coma Science Group Collaborators
dc.contributor.author Deco, Gustavo
dc.contributor.author Laureys, Steven
dc.contributor.author Zamora-López, Gorka
dc.contributor.author Annen, Jitka
dc.date.accessioned 2023-07-04T06:40:29Z
dc.date.available 2023-07-04T06:40:29Z
dc.date.issued 2023
dc.description.abstract The study of the brain's dynamical activity is opening a window to help the clinical assessment of patients with disorders of consciousness. For example, glucose uptake and the dysfunctional spread of naturalistic and synthetic stimuli has proven useful to characterize hampered consciousness. However, understanding of the mechanisms behind loss of consciousness following brain injury is still missing. Here, we study the propagation of endogenous and in-silico exogenous perturbations in patients with disorders of consciousness, based upon directed and causal interactions estimated from resting-state fMRI data, fitted to a linear model of activity propagation. We found that patients with disorders of consciousness suffer decreased capacity for neural propagation and responsiveness to events, and that this can be related to severe reduction of glucose metabolism as measured with [18F]FDG-PET. In particular, we show that loss of consciousness is related to the malfunctioning of two neural circuits: the posterior cortical regions failing to convey information, in conjunction with reduced broadcasting of information from subcortical, temporal, parietal and frontal regions. These results shed light on the mechanisms behind disorders of consciousness, triangulating network function with basic measures of brain integrity and behavior.
dc.description.sponsorship AstraZeneca Foundation; Belgian Federal Science Policy Office; University and University Hospital of Liege; European Space Agency; Fondazione Europea di Ricerca Biomedica; Fonds Léon Fredericq; Fundaçao˜ Bial; Human Brain Project, Grant/Award Numbers: 785907, 945539; Mind Science Foundation and the European Commission; Swiss National Science Foundation Sinergia, Grant/Award Number: 170873; The Belgian National Funds for Scientific Research (FRS-FNRS); The Belgian Federal Science Policy Office (BELSPO); The DOCMA Project, Grant/Award Number: EU-H2020-MSCARISE-778234; The Fund Generet; The King Baudouin Foundation; FLAG-ERA JTC; The Spanish Ministry Project; The Catalan Research Group Support; Spanish Ministry of Science, Innovation and Universities; State Research Agency; European Regional Development Funds.
dc.format.mimetype application/pdf
dc.identifier.citation Panda R, López-González A, Gilson M, Gosseries O, Thibaut A, Frasso G, Cecconi B, Escrichs A, Coma Science Group Collaborators, Deco G, Laureys S, Zamora-López G, Annen J. Whole-brain analyses indicate the impairment of posterior integration and thalamo-frontotemporal broadcasting in disorders of consciousness. Hum Brain Mapp. 2023;44(11):4352-71. DOI: 10.1002/hbm.26386
dc.identifier.doi http://dx.doi.org/10.1002/hbm.26386
dc.identifier.issn 1065-9471
dc.identifier.uri http://hdl.handle.net/10230/57444
dc.language.iso eng
dc.publisher Wiley
dc.relation.ispartof Human Brain Mapping. 2023;44(11):4352-71.
dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/785907
dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/945539
dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/778234
dc.relation.projectID info:eu-repo/grantAgreement/ES/2PE/PCI2018-092891
dc.relation.projectID info:eu-repo/grantAgreement/ES/1PE/PSI2016-75688-P
dc.relation.projectID info:eu-repo/grantAgreement/ES/2PE/PID2019-105772GB-I00
dc.rights © 2023 The Authors. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject.keyword broadcasting of information
dc.subject.keyword disorders of consciousness
dc.subject.keyword in-silico exogenous perturbations
dc.subject.keyword integration of information
dc.title Whole-brain analyses indicate the impairment of posterior integration and thalamo-frontotemporal broadcasting in disorders of consciousness
dc.type info:eu-repo/semantics/article
dc.type.version info:eu-repo/semantics/publishedVersion

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