Impact of preformed and de novo anti-HLA DP antibodies in renal allograft survival.

Redondo Pachón, María Dolores; Pascual Santos, Julio; Pérez-Sáez, María José; García, Carmen; Hernández, Juan José; Gimeno Beltran, Javier; Mir Fontana, M. Luisa; Crespo Barrio, Marta

Impact of preformed and de novo anti-HLA DP antibodies in renal allograft survival.

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dc.contributor.author Redondo Pachón, María Doloresca
dc.contributor.author Pascual Santos, Julioca
dc.contributor.author Pérez-Sáez, María Joséca
dc.contributor.author García, Carmenca
dc.contributor.author Hernández, Juan Joséca
dc.contributor.author Gimeno Beltran, Javierca
dc.contributor.author Mir Fontana, M. Luisaca
dc.contributor.author Crespo Barrio, Martaca
dc.date.accessioned 2016-02-19T09:52:05Z
dc.date.issued 2016
dc.description.abstract The influence of antibodies against HLA-DP antigens detected with solid-phase assays on graft survival after kidney transplantation (KT) is uncertain. We evaluated with Luminex® the prevalence of pre- and posttransplant DP antibodies in 440 KT patients and their impact on graft survival. For 291 patients with available pretransplant samples, DP antibodies were present in 39.7% KT with pretransplant HLA antibodies and 47.7% with DSA. Graft survival of KT with pretransplant class-II DSA was worse than with non-DSA (p=0.01). DP antibodies did not influence graft survival. Of 346 patients monitored post-KT, 17.1% had HLA class-II antibodies, 56% with DP antibodies. Class-II DSA was detected in 39%, 60.9% of them had DP antibodies. Graft survival was worse in patients with class-II DSA (p=0.022). DP antibodies did not change these results. The presence of isolated DP antibodies was a rare event both pre- and posttransplantation (1.03 and 0.86%). The presence of pretransplant and posttransplant DSA is associated with a negative impact on graft survival. However, the presence of DP antibodies does not modify this impact significantly.ca
dc.description.sponsorship This study was performed with funding from the projects PI10/01370, PI13/00598 Spanish Ministry of Health ISCIII FISFEDER,/nMarato TV3 137/C/2012 and RedinRen RD12/0021/0024. DRP did this study as part of her doctoral thesis program at Universitat/nAutonoma of Barcelona.
dc.format.mimetype application/pdfca
dc.identifier.citation Redondo-Pachón D, Pascual J, Pérez-Sáez MJ, García C, Hernández JJ, Gimeno J. et al. Impact of preformed and de novo anti-HLA DP antibodies in renal allograft survival. Transpl Immunol. 2016 Feb;34:1-7. doi: 10.1016/j.trim.2015.11.002.ca
dc.identifier.doi http://dx.doi.org/10.1016/j.trim.2015.11.002
dc.identifier.issn 0966-3274
dc.identifier.uri http://hdl.handle.net/10230/25907
dc.language.iso engca
dc.publisher Elsevierca
dc.relation.ispartof Transplant Immunology. 2016 Feb;34:1-7
dc.rights © 2015 Elsevier . Redondo-Pachón D, Pascual J, Pérez-Sáez MJ, García C, Hernández JJ, Gimeno J. et al. Impact of preformed and de novo anti-HLA DP antibodies in renal allograft survival. Transpl Immunol. 2016 Feb;34:1-7. doi: 10.1016/j.trim.2015.11.002.ca
dc.rights.accessRights info:eu-repo/semantics/openAccessca
dc.subject.other Ronyons -- Trasplantacióca
dc.subject.other Anticossosca
dc.title Impact of preformed and de novo anti-HLA DP antibodies in renal allograft survival.ca
dc.type info:eu-repo/semantics/articleca
dc.type.version info:eu-repo/semantics/acceptedVersionca

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