Impact of preformed and de novo anti-HLA DP antibodies in renal allograft survival.

Redondo Pachón, María Dolores; Pascual Santos, Julio; Pérez-Sáez, María José; García, Carmen; Hernández, Juan José; Gimeno Beltran, Javier; Mir Fontana, M. Luisa; Crespo Barrio, Marta

doi:http://dx.doi.org/10.1016/j.trim.2015.11.002

Impact of preformed and de novo anti-HLA DP antibodies in renal allograft survival.

Citation

Redondo-Pachón D, Pascual J, Pérez-Sáez MJ, García C, Hernández JJ, Gimeno J. et al. Impact of preformed and de novo anti-HLA DP antibodies in renal allograft survival. Transpl Immunol. 2016 Feb;34:1-7. doi: 10.1016/j.trim.2015.11.002.

Abstract

The influence of antibodies against HLA-DP antigens detected with solid-phase assays on graft survival after kidney transplantation (KT) is uncertain. We evaluated with Luminex® the prevalence of pre- and posttransplant DP antibodies in 440 KT patients and their impact on graft survival. For 291 patients with available pretransplant samples, DP antibodies were present in 39.7% KT with pretransplant HLA antibodies and 47.7% with DSA. Graft survival of KT with pretransplant class-II DSA was worse than with non-DSA (p=0.01). DP antibodies did not influence graft survival. Of 346 patients monitored post-KT, 17.1% had HLA class-II antibodies, 56% with DP antibodies. Class-II DSA was detected in 39%, 60.9% of them had DP antibodies. Graft survival was worse in patients with class-II DSA (p=0.022). DP antibodies did not change these results. The presence of isolated DP antibodies was a rare event both pre- and posttransplantation (1.03 and 0.86%). The presence of pretransplant and posttransplant DSA is associated with a negative impact on graft survival. However, the presence of DP antibodies does not modify this impact significantly.