Optical monitoring of labile zinc inside metastatic cells with plasmonic chemonanosensors

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• dc.contributor.author Zhou, Ting
• dc.contributor.author Vicente García, Rubén, 1978-
• dc.contributor.author Rivera Gil, Pilar, 1976-
• dc.date.accessioned 2024-11-15T07:15:03Z
• dc.date.available 2024-11-15T07:15:03Z
• dc.date.issued 2024
• dc.description.abstract We report the development and characterization of an optical nanosensor for the detection of labile zinc in biological environments. The readout is based on surface-enhanced Raman scattering promoted by a Raman reporter conjugated to the inner plasmonic cavity of hollow silica nanocapsules. We quantify Zn2+ by obtaining the ratio between a Zn2+-sensitive band and a Zn2+-insensitive band. The Raman reporter measures within the range from 10-5 to 10-11 M and exhibits a limit of detection of 10-11.72 M. The nanosensor discriminates between intracellular and extracellular Zn2+ concentrations.
• dc.description.sponsorship Pilar Rivera Gil acknowledges the Ministry of Science, Innovation and Universities (MICINN) and the AEI (AEI-PID2019-106755RB-I00 and PID2022-140423NB-I00) and the AGAUR (2021 SGR 00175 and 2021 PROD 00041) for financial support. T.Z. and Pilar Rivera Gil appreciate the financial support from the China Scholarship Council (CSC) by a State Scholarship Fund (NSCIS no. 202008350121). R.V. acknowledges AEI (PID2022-136511OB-I00) for financial support.
• dc.format.mimetype application/pdf
• dc.identifier.citation Zhou T, Vicente R, Rivera-Gil P. Optical monitoring of labile zinc inside metastatic cells with plasmonic chemonanosensors. ACS Omega. 2024 Oct 3;9(41):42183-92. DOI: 10.1021/acsomega.4c03631
• dc.identifier.doi http://dx.doi.org/10.1021/acsomega.4c03631
• dc.identifier.issn 2470-1343
• dc.identifier.uri http://hdl.handle.net/10230/68700
• dc.language.iso eng
• dc.publisher American Chemical Society (ACS)
• dc.relation.ispartof ACS Omega. 2024 Oct 3;9(41):42183-92
• dc.relation.projectID info:eu-repo/grantAgreement/ES/2PE/PID2019-106755RB-I00
• dc.relation.projectID info:eu-repo/grantAgreement/ES/3PE/PID2022-140423NB-I00
• dc.relation.projectID info:eu-repo/grantAgreement/ES/3PE/PID2022-136511OB-I00
• dc.rights This article is licensed under CC-BY-NC-ND 4.0 (https://creativecommons.org/licenses/by-nc-nd/4.0/).
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/4.0/
• dc.subject.keyword Cancer
• dc.subject.keyword Cells
• dc.subject.keyword Nanodevices
• dc.subject.keyword Raman spectroscopy
• dc.subject.keyword Zinc
• dc.title Optical monitoring of labile zinc inside metastatic cells with plasmonic chemonanosensors
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion