Optical monitoring of labile zinc inside metastatic cells with plasmonic chemonanosensors
Optical monitoring of labile zinc inside metastatic cells with plasmonic chemonanosensors
Citació
- Zhou T, Vicente R, Rivera-Gil P. Optical monitoring of labile zinc inside metastatic cells with plasmonic chemonanosensors. ACS Omega. 2024 Oct 3;9(41):42183-92. DOI: 10.1021/acsomega.4c03631
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Descripció
Resum
We report the development and characterization of an optical nanosensor for the detection of labile zinc in biological environments. The readout is based on surface-enhanced Raman scattering promoted by a Raman reporter conjugated to the inner plasmonic cavity of hollow silica nanocapsules. We quantify Zn2+ by obtaining the ratio between a Zn2+-sensitive band and a Zn2+-insensitive band. The Raman reporter measures within the range from 10-5 to 10-11 M and exhibits a limit of detection of 10-11.72 M. The nanosensor discriminates between intracellular and extracellular Zn2+ concentrations.