Adaptive NK cell response to human cytomegalovirus: Facts and open issues
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- dc.contributor.author López-Botet, M. (Miguel)
- dc.contributor.author Maria, Andrea de
- dc.contributor.author Muntasell i Castellví, Aura, 1972-
- dc.contributor.author Della Chiesa, Mariella
- dc.contributor.author Vilches, Carlos
- dc.date.accessioned 2023-01-17T12:57:47Z
- dc.date.available 2023-01-17T12:57:47Z
- dc.date.issued 2023
- dc.description.abstract Human cytomegalovirus (HCMV) infection exerts broad effects on the immune system. These include the differentiation and persistent expansion of a mature NK cell subset which displays a characteristic phenotypic and functional profile hallmarked by expression of the HLA-E-specific CD94/NKG2C activating receptor. Based on our experience and recent advances in the field, we overview the adaptive features of the NKG2C+ NK cell response, discussing observations and open questions on: (a) the mechanisms and influence of viral and host factors; (b) the existence of other NKG2C- NK cell subsets sharing adaptive features; (c) the development and role of adaptive NKG2C+ NK cells in the response to HCMV in hematopoietic and solid organ transplant patients; (d) their relation with other viral infections, mainly HIV-1; and (e) current perspectives for their use in adoptive immunotherapy of cancer.
- dc.description.sponsorship Research is supported by: Agencia Estatal de Investigación-FEDER (PID2019–110609RB-C21-C22/AEI/10.13039/501100011033); Fundació La Marató de TV3 (201822–10); Ministero dell’Istruzione (MIUR) - FRA 219; Ministero dell’Istruzione (MIUR): FISR2020IP_02937; ISCiii/FEDER (PI19/00328; PI22/00040) and CIBERONC.
- dc.format.mimetype application/pdf
- dc.identifier.citation López-Botet M, De Maria A, Muntasell A, Della Chiesa M, Vilches C. Adaptive NK cell response to human cytomegalovirus: Facts and open issues. Semin Immunol. 2023 Jan;65:101706. DOI: 10.1016/j.smim.2022.101706
- dc.identifier.doi http://dx.doi.org/10.1016/j.smim.2022.101706
- dc.identifier.issn 1044-5323
- dc.identifier.uri http://hdl.handle.net/10230/55316
- dc.language.iso eng
- dc.publisher Elsevier
- dc.relation.ispartof Semin Immunol. 2023 Jan;65:101706
- dc.relation.projectID info:eu-repo/grantAgreement/ES/2PE/PID2019–110609RB-C21
- dc.relation.projectID info:eu-repo/grantAgreement/ES/2PE/PID2019–110609RB-C22
- dc.rights © 2022 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.rights.uri http://creativecommons.org/licenses/by/4.0/
- dc.subject.keyword Cancer
- dc.subject.keyword Cytomegalovirus
- dc.subject.keyword Infection
- dc.subject.keyword NK cells
- dc.subject.keyword NKG2C
- dc.subject.keyword Transplantation
- dc.title Adaptive NK cell response to human cytomegalovirus: Facts and open issues
- dc.type info:eu-repo/semantics/article
- dc.type.version info:eu-repo/semantics/publishedVersion