The INSIDEOUT framework provides precise signatures of the balance of intrinsic and extrinsic dynamics in brain states

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• dc.contributor.author Deco, Gustavo
• dc.contributor.author Sanz Perl, Yonatan
• dc.contributor.author Bocaccio, Hernan
• dc.contributor.author Tagliazucchi, Enzo
• dc.contributor.author Kringelbach, Morten L.
• dc.date.accessioned 2023-03-03T07:42:57Z
• dc.date.available 2023-03-03T07:42:57Z
• dc.date.issued 2022
• dc.description.abstract Finding precise signatures of different brain states is a central, unsolved question in neuroscience. We reformulated the problem to quantify the ‘inside out’ balance of intrinsic and extrinsic brain dynamics in brain states. The difference in brain state can be described as differences in the detailed causal interactions found in the underlying intrinsic brain dynamics. We used a thermodynamics framework to quantify the breaking of the detailed balance captured by the level of asymmetry in temporal processing, i.e. the arrow of time. Specifically, the temporal asymmetry was computed by the time-shifted correlation matrices for the forward and reversed time series, reflecting the level of non-reversibility/non-equilibrium. We found precise, distinguishing signatures in terms of the reversibility and hierarchy of large-scale dynamics in three radically different brain states (awake, deep sleep and anaesthesia) in electrocorticography data from non-human primates. Significantly lower levels of reversibility were found in deep sleep and anaesthesia compared to wakefulness. Non-wakeful states also showed a flatter hierarchy, reflecting the diversity of the reversibility across the brain. Overall, this provides signatures of the breaking of detailed balance in different brain states, perhaps reflecting levels of conscious awareness.
• dc.description.sponsorship G.D. was supported by the Human Brain Project Specific Grant Agreement 3 Grant agreement no. 945539 and by the Spanish Research Project AWAKENING: using whole-brain models perturbational approaches for predicting external stimulation to force transitions between different brain states, ref. PID2019-105772GB-I00/AEI/10.13039/501100011033, financed by the Spanish Ministry of Science, Innovation and Universities (MCIU), State Research Agency (AEI). Y.S.P is supported by European Union’s Horizon 2020 research and innovation programme under the Marie Sklodowska-Curie grant 896354. E.T. is supported by grants PICT-2018-03103 and PICT-2019-02294 funded by Agencia I+D+I (Argentina) and by a Mercator fellowship granted by the German Research Foundation. M.L.K. is supported by the Center for Music in the Brain, funded by the Danish National Research Foundation (DNRF117), and Centre for Eudaimonia and Human Flourishing at Linacre College funded by the Pettit and Carlsberg Foundations.
• dc.format.mimetype application/pdf
• dc.identifier.citation Deco G, Sanz Perl Y, Bocaccio H, Tagliazucchi E, Kringelbach ML. The INSIDEOUT framework provides precise signatures of the balance of intrinsic and extrinsic dynamics in brain states. Commun Biol. 2022;5:572. DOI: 10.1038/s42003-022-03505-7
• dc.identifier.doi http://dx.doi.org/10.1038/s42003-022-03505-7
• dc.identifier.issn 2399-3642
• dc.identifier.uri http://hdl.handle.net/10230/56019
• dc.language.iso eng
• dc.publisher Nature Research
• dc.relation.ispartof Communications Biology. 2022;5:572.
• dc.relation.isreferencedby https://static-content.springer.com/esm/art%3A10.1038%2Fs42003-022-03505-7/MediaObjects/42003_2022_3505_MOESM1_ESM.pdf
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• dc.relation.isreferencedby https://static-content.springer.com/esm/art%3A10.1038%2Fs42003-022-03505-7/MediaObjects/42003_2022_3505_MOESM3_ESM.pdf
• dc.relation.isreferencedby https://static-content.springer.com/esm/art%3A10.1038%2Fs42003-022-03505-7/MediaObjects/42003_2022_3505_MOESM4_ESM.xlsx
• dc.relation.isreferencedby https://static-content.springer.com/esm/art%3A10.1038%2Fs42003-022-03505-7/MediaObjects/42003_2022_3505_MOESM5_ESM.pdf
• dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/945539
• dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/896354
• dc.relation.projectID info:eu-repo/grantAgreement/ES/2PE/PID2019-105772GB-I00
• dc.rights © The Author(s) 2022. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/ licenses/by/4.0/
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by/4.0/
• dc.subject.keyword Computational neuroscience
• dc.subject.keyword Neuroscience
• dc.title The INSIDEOUT framework provides precise signatures of the balance of intrinsic and extrinsic dynamics in brain states
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion