ITBS-induced LTP-like plasticity parallels oscillatory activity changes in the primary sensory and motor areas of macaque monkeys

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  • dc.contributor.author Papazachariadis, Odysseasca
  • dc.contributor.author Dante, Vittorioca
  • dc.contributor.author Verschure, Paul F. M. J.ca
  • dc.contributor.author Del Giudice, Paoloca
  • dc.contributor.author Ferraina, Stefanoca
  • dc.date.accessioned 2016-02-18T15:22:22Z
  • dc.date.available 2016-02-18T15:22:22Z
  • dc.date.issued 2014
  • dc.description.abstract Recently, neuromodulation techniques based on the use of repetitive transcranial magnetic stimulation (rTMS) have been/nproposed as a non-invasive and efficient method to induce in vivo long-term potentiation (LTP)-like aftereffects. However,/nthe exact impact of rTMS-induced perturbations on the dynamics of neuronal population activity is not well understood./nHere, in two monkeys, we examine changes in the oscillatory activity of the sensorimotor cortex following an intermittent/ntheta burst stimulation (iTBS) protocol. We first probed iTBS modulatory effects by testing the iTBS-induced facilitation of/nsomatosensory evoked potentials (SEP). Then, we examined the frequency information of the electrocorticographic signal,/nobtained using a custom-made miniaturised multi-electrode array for electrocorticography, after real or sham iTBS. We/nobserved that iTBS induced facilitation of SEPs and influenced spectral components of the signal, in both animals. The latter/neffect was more prominent on the h band (4–8 Hz) and the high c band (55–90 Hz), de-potentiated and potentiated/nrespectively. We additionally found that the multi-electrode array uniformity of b (13–26 Hz) and high c bands were also/nafflicted by iTBS. Our study suggests that enhanced cortical excitability promoted by iTBS parallels a dynamic reorganisation/nof the interested neural network. The effect in the c band suggests a transient local modulation, possibly at the level of/nsynaptic strength in interneurons. The effect in the h band suggests the disruption of temporal coordination on larger/nspatial scales.ca
  • dc.format.mimetype application/pdfca
  • dc.identifier.citation Papazachariadis O, Dante V, Verschure PFMJ, Giudice PD, Ferraina S. ITBS-induced LTP-like plasticity parallels oscillatory activity changes in the primary sensory and motor areas of macaque monkeys. PLoS ONE. 2014;9(11):1-10. DOI: 10.1371/journal.pone.0112504
  • dc.identifier.doi http://dx.doi.org/10.1371/journal.pone.0112504
  • dc.identifier.issn 1932-6203
  • dc.identifier.uri http://hdl.handle.net/10230/25894
  • dc.language.iso engca
  • dc.publisher Public Library of Scienceca
  • dc.relation.ispartof PLoS ONE. 2014;9(11):1-10
  • dc.rights © 2014 Papazachariadis et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits/nunrestricted use, distribution, and reproduction in any medium, provided the original author and source are creditedca
  • dc.rights.accessRights info:eu-repo/semantics/openAccessca
  • dc.rights.uri http://creativecommons.org/licenses/by/4.0/
  • dc.title ITBS-induced LTP-like plasticity parallels oscillatory activity changes in the primary sensory and motor areas of macaque monkeysca
  • dc.type info:eu-repo/semantics/articleca
  • dc.type.version info:eu-repo/semantics/publishedVersionca

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