Autophagy: a decisive process for stemness

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dc.contributor.authorGarcía Prat, Lauraca
dc.contributor.authorMartínez Vicente, Martaca
dc.contributor.authorMuñoz Cánoves, Pura, 1962-ca
dc.date.accessioned2016-06-15T16:01:16Z
dc.date.available2016-06-15T16:01:16Z
dc.date.issued2016
dc.description.abstractMature skeletal muscle is a stable tissue imposing low homeostatic demand on its stem cells, which remain in a quiescent state in their niche over time. We have shown that these long-lived resting stem cells attenuate proteotoxicity and avoid senescence through basal autophagy. This protective "clean-up" system is lost during aging, resulting in stem cell regenerative decline. Thus, autophagy is required for muscle stem cell homeostasis maintenance.ca
dc.description.sponsorshipWork in the authors’ laboratories has been supported by: MINECO, Spain SAF2012-38547, SAF2015-67369-R, AFM, E-Rare/Eranet, Fundació Marató-TV3, MDA, EU-FP7 (Myoage, Optistem and Endostem) and DuchennePP-NL, to PM-C; and ISCIII, Spain (FISPS09/01267, FIS-PI13/02512, CP09/00184, PI14/01529) and CIBERNED to MM-V. L.G.-P. was supported by a Predoctoral Fellowship from Programa de Formación de Personal Investigador (Spain).
dc.format.mimetypeapplication/pdfca
dc.identifier.citationGarcía-Prat L, Martínez-Vicente M, Muñoz-Cánoves P. Autophagy: a decisive process for stemness. Oncotarget. 2016; 7(11): 12286-12288. DOI 10.18632/oncotarget.7766ca
dc.identifier.doihttp://dx.doi.org/10.18632/oncotarget.7766
dc.identifier.issn1949-2553
dc.identifier.urihttp://hdl.handle.net/10230/26920
dc.language.isoengca
dc.publisherImpact Journalsca
dc.relation.ispartofOncotarget. 2016; 7(11): 12286-1228
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/3PN/SAF2012-38547
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/1PE/SAF2015-67369-R
dc.rightsPublished originally by Impact Journals at http://dx.doi.org/10.18632/oncotarget.7766 under a Creative Commons Attribution 3.0 License.ca
dc.rights.accessRightsinfo:eu-repo/semantics/openAccessca
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/ca
dc.subject.keywordAging
dc.subject.keywordAutophagy
dc.subject.keywordMuscle
dc.subject.keywordSenescence
dc.subject.keywordStem cells
dc.subject.otherMúsculs -- Envellimentca
dc.titleAutophagy: a decisive process for stemnessca
dc.typeinfo:eu-repo/semantics/articleca
dc.type.versioninfo:eu-repo/semantics/publishedVersionca

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