Autophagy: a decisive process for stemness

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• dc.contributor.author García Prat, Lauraca
• dc.contributor.author Martínez Vicente, Martaca
• dc.contributor.author Muñoz Cánoves, Pura, 1962-ca
• dc.date.accessioned 2016-06-15T16:01:16Z
• dc.date.available 2016-06-15T16:01:16Z
• dc.date.issued 2016
• dc.description.abstract Mature skeletal muscle is a stable tissue imposing low homeostatic demand on its stem cells, which remain in a quiescent state in their niche over time. We have shown that these long-lived resting stem cells attenuate proteotoxicity and avoid senescence through basal autophagy. This protective "clean-up" system is lost during aging, resulting in stem cell regenerative decline. Thus, autophagy is required for muscle stem cell homeostasis maintenance.ca
• dc.description.sponsorship Work in the authors’ laboratories has been supported by: MINECO, Spain SAF2012-38547, SAF2015-67369-R, AFM, E-Rare/Eranet, Fundació Marató-TV3, MDA, EU-FP7 (Myoage, Optistem and Endostem) and DuchennePP-NL, to PM-C; and ISCIII, Spain (FISPS09/01267, FIS-PI13/02512, CP09/00184, PI14/01529) and CIBERNED to MM-V. L.G.-P. was supported by a Predoctoral Fellowship from Programa de Formación de Personal Investigador (Spain).
• dc.format.mimetype application/pdfca
• dc.identifier.citation García-Prat L, Martínez-Vicente M, Muñoz-Cánoves P. Autophagy: a decisive process for stemness. Oncotarget. 2016; 7(11): 12286-12288. DOI 10.18632/oncotarget.7766ca
• dc.identifier.doi http://dx.doi.org/10.18632/oncotarget.7766
• dc.identifier.issn 1949-2553
• dc.identifier.uri http://hdl.handle.net/10230/26920
• dc.language.iso engca
• dc.publisher Impact Journalsca
• dc.relation.ispartof Oncotarget. 2016; 7(11): 12286-1228
• dc.relation.projectID info:eu-repo/grantAgreement/ES/3PN/SAF2012-38547
• dc.relation.projectID info:eu-repo/grantAgreement/ES/1PE/SAF2015-67369-R
• dc.rights Published originally by Impact Journals at http://dx.doi.org/10.18632/oncotarget.7766 under a Creative Commons Attribution 3.0 License.ca
• dc.rights.accessRights info:eu-repo/semantics/openAccessca
• dc.rights.uri http://creativecommons.org/licenses/by/3.0/ca
• dc.subject.keyword Aging
• dc.subject.keyword Autophagy
• dc.subject.keyword Muscle
• dc.subject.keyword Senescence
• dc.subject.keyword Stem cells
• dc.subject.other Músculs -- Envellimentca
• dc.title Autophagy: a decisive process for stemnessca
• dc.type info:eu-repo/semantics/articleca
• dc.type.version info:eu-repo/semantics/publishedVersionca