Autophagy: a decisive process for stemness

García Prat, Laura; Martínez Vicente, Marta; Muñoz Cánoves, Pura, 1962-

doi:http://dx.doi.org/10.18632/oncotarget.7766

Autophagy: a decisive process for stemness

Llicència

Citació

García-Prat L, Martínez-Vicente M, Muñoz-Cánoves P. Autophagy: a decisive process for stemness. Oncotarget. 2016; 7(11): 12286-12288. DOI 10.18632/oncotarget.7766

Resum

Mature skeletal muscle is a stable tissue imposing low homeostatic demand on its stem cells, which remain in a quiescent state in their niche over time. We have shown that these long-lived resting stem cells attenuate proteotoxicity and avoid senescence through basal autophagy. This protective "clean-up" system is lost during aging, resulting in stem cell regenerative decline. Thus, autophagy is required for muscle stem cell homeostasis maintenance.