Cognitive performance in healthy older adults relates to spontaneous switching between states of functional connectivity during rest

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• dc.contributor.author Cabral, Joana
• dc.contributor.author Vidaurre, Diego
• dc.contributor.author Marques, Paulo
• dc.contributor.author Magalhães, Ricardo
• dc.contributor.author Moreira, Pedro Silva
• dc.contributor.author Soares, José Miguel
• dc.contributor.author Deco, Gustavo
• dc.contributor.author Sousa, Nuno
• dc.contributor.author Kringelbach, Morten L.
• dc.date.accessioned 2019-06-17T10:45:22Z
• dc.date.available 2019-06-17T10:45:22Z
• dc.date.issued 2017
• dc.description.abstract Growing evidence has shown that brain activity at rest slowly wanders through a repertoire of different states, where whole-brain functional connectivity (FC) temporarily settles into distinct FC patterns. Nevertheless, the functional role of resting-state activity remains unclear. Here, we investigate how the switching behavior of resting-state FC relates with cognitive performance in healthy older adults. We analyse resting-state fMRI data from 98 healthy adults previously categorized as being among the best or among the worst performers in a cohort study of >1000 subjects aged 50+ who underwent neuropsychological assessment. We use a novel approach focusing on the dominant FC pattern captured by the leading eigenvector of dynamic FC matrices. Recurrent FC patterns – or states – are detected and characterized in terms of lifetime, probability of occurrence and switching profiles. We find that poorer cognitive performance is associated with weaker FC temporal similarity together with altered switching between FC states. These results provide new evidence linking the switching dynamics of FC during rest with cognitive performance in later life, reinforcing the functional role of resting-state activity for effective cognitive processing.
• dc.description.sponsorship J.C. and M.L.K. are supported by the ERC Consolidator Grant: CAREGIVING (n. 615539) and the Center for Music in the Brain, funded by the Danish National Research Foundation (DNRF117). D.V. is supported by a Wellcome Trust Strategic Award (098369/Z/12/Z). P.M. is supported by the Fundação Calouste Gulbenkian (Portugal) Grant Number: P-139977: ‘Better mental health during ageing based on temporal prediction of individual brain ageing trajectories (TEMPO)’. R.M. and P.S.M. are supported by FCT fellowship grants from the PhD-iHES program with numbers PDE/BDE/113604/2015 and PDE/BDE/113601/2015. G.D. is supported by the ERC Advanced Grant DYSTRUCTURE (n. 295129), by the Spanish Research Project PSI2016-75688-P (AEI/FEDER) and by the the European Union’s Horizon 2020 research and innovation programme under grant agreement n. 720270 (HBP SGA1). This project was financed by the Fundação Calouste Gulbenkian (Portugal) (Contract grant number: P-139977; project “Better mental health during ageing based on temporal prediction of individual brain ageing trajectories (TEMPO)”), co-financed by Portuguese North Regional Operational Program (ON.2) under the National Strategic Reference Framework (QREN), through the European Regional Development Fund (FEDER) as well as the Projecto Estratégico co-funded by FCT (PEst-C/SAU/LA0026-/2013) and the European Regional Development Fund COMPETE (FCOMP-01-0124-FEDER-037298) and under the scope of the project NORTE-01-0145-FEDER-000013, supported by the Northern Portugal Regional Operational Programme (NORTE 2020) under the Portugal 2020 Partnership Agreement through the European Regional Development Fund.
• dc.format.mimetype application/pdf
• dc.identifier.citation Cabral J, Vidaurre D, Marques P, Magalhães R, Moreira PS, Soares JM, Deco G, Sousa N, Kringelbach ML. Cognitive performance in healthy older adults relates to spontaneous switching between states of functional connectivity during rest. Sci Rep. 2017;7:5135. DOI: 10.1038/s41598-017-05425-7
• dc.identifier.doi http://dx.doi.org/10.1038/s41598-017-05425-7
• dc.identifier.issn 2045-2322
• dc.identifier.uri http://hdl.handle.net/10230/41772
• dc.language.iso eng
• dc.publisher Nature Research
• dc.relation.ispartof Scientific Reports. 2017;7:5135
• dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/720270
• dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/615539
• dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/295129
• dc.relation.projectID info:eu-repo/grantAgreement/ES/1PE/PSI2016-75688-P
• dc.rights © Springer Nature Publishing AG https://dx.doi.org/10.1038/s41598-017-05425-7 This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri https://creativecommons.org/licenses/by/4.0/
• dc.title Cognitive performance in healthy older adults relates to spontaneous switching between states of functional connectivity during rest
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion