Reward learning requires activity of matrix metalloproteinase-9 in the central amygdala

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  • dc.contributor.author Knapska, Ewelinaca
  • dc.contributor.author Lioudyno, Victoriaca
  • dc.contributor.author Kiryk, Annaca
  • dc.contributor.author Mikosz, Martaca
  • dc.contributor.author Górkiewicz, Tomaszca
  • dc.contributor.author Michaluk, Piotrca
  • dc.contributor.author Gawlak, Maciejca
  • dc.contributor.author Chaturvedi, Mayankca
  • dc.contributor.author Mochol, Gabrielaca
  • dc.contributor.author Balcerzyk, Marcinca
  • dc.contributor.author Wójcik, Daniel K.ca
  • dc.contributor.author Wilczynski, Grzegorz M.ca
  • dc.contributor.author Kaczmarek, Leszekca
  • dc.date.accessioned 2018-07-25T12:46:30Z
  • dc.date.available 2018-07-25T12:46:30Z
  • dc.date.issued 2013
  • dc.description.abstract Learning how to avoid danger and pursue reward depends on negative emotions motivating aversive learning and positive emotions motivating appetitive learning. The amygdala is a key component of the brain emotional system; however, an understanding of how various emotions are differentially processed in the amygdala has yet to be achieved.Wereport that matrix metalloproteinase-9 (MMP-9, extracellularly operating enzyme) in the central nucleus of the amygdala (CeA) is crucial for appetitive, but not for aversive, learning in mice. The knock-out of MMP-9 impairs appetitively motivated conditioning, but not an aversive one. MMP-9 is present at the excitatory synapses in the CeA with its activity greatly enhanced after the appetitive training. Finally, blocking extracellular MMP-9 activity with its inhibitor TIMP-1 provides evidence that local MMP-9 activity in the CeA is crucial for the appetitive, but not for aversive, learning.en
  • dc.description.sponsorship This work was supported in part by COST Action Grant BM0901, Polish Ministry of Science and Higher Education (E.K. and L.K.), andTEAMproject from the Foundation for Polish Science (L.K.). E.K. was supported by the Foundation for Polish Science through itsHOMINGprogram.
  • dc.format.mimetype application/pdf
  • dc.identifier.citation Knapska E, Lioudyno V, Kiryk A, Mikosz M, Górkiewicz T, Michaluk P, Gawlak M, Chaturvedi M, Mochol G, Balcerzyk M, Wojcik DK, Wilczynski GM, Kaczmarek L. Reward learning requires activity of matrix metalloproteinase-9 in the central amygdala. J Neurosci. 2013;33(36):14591-600. DOI: 10.1523/JNEUROSCI.5239-12.2013
  • dc.identifier.doi http://dx.doi.org/10.1523/JNEUROSCI.5239-12.2013
  • dc.identifier.issn 0270-6474
  • dc.identifier.uri http://hdl.handle.net/10230/35263
  • dc.language.iso eng
  • dc.publisher Society for Neuroscienceca
  • dc.relation.ispartof The Journal of Neuroscience. 2013;33(36):14591-600
  • dc.rights © The Authors. Published by the Society for Neuroscience http://www.jneurosci.org/content/33/36/14591. This article is published under a Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/
  • dc.rights.accessRights info:eu-repo/semantics/openAccess
  • dc.rights.uri http://creativecommons.org/licenses/by-nc-sa/3.0/
  • dc.title Reward learning requires activity of matrix metalloproteinase-9 in the central amygdalaca
  • dc.type info:eu-repo/semantics/article
  • dc.type.version info:eu-repo/semantics/publishedVersion

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