Risk of a second skin cancer in a cohort of patients with nonmelanoma skin cancer -basal cell carcinoma or squamous cell carcinoma-treated with mohs micrographic surgery: a national prospective cohort study

Mostra el registre complet Registre parcial de l'ítem

  • dc.contributor.author Miñano Medrano, R.
  • dc.contributor.author Sánchez-Schmidt, Julia Maria
  • dc.contributor.author Toll Abelló, Agustín
  • dc.contributor.author García-Doval, Ignacio
  • dc.date.accessioned 2022-10-04T07:40:01Z
  • dc.date.available 2022-10-04T07:40:01Z
  • dc.date.issued 2022
  • dc.description.abstract Objective: patients with nonmelanoma skin cancer (NMSC)-ie, basal cell carcinoma (BCC) or squamous cell carcinoma (SCC)-have an increased risk of developing a second skin cancer. The aim of this study was to describe the frequency, incidence per 1000 person-years, and predictors of a second skin cancer in a cohort of patients with NMSC treated with Mohs micrographic surgery (MMS). Material and methods: prospective study of a national cohort of patients with NMSC who underwent MMS at 22 Spanish hospitals between July 2013 and February 2020; case data were recorded in the REGESMOHS registry. The study variables included demographic characteristics, frequency and incidence per 1000 person-years of second skin cancers diagnosed during the study period, and risk factors identified using mixed-effects logistic regression. Results: we analyzed data for 4768 patients who underwent MMS; 4397 (92%) had BCC and 371 (8%) had SCC. Mean follow-up was 2.4 years. Overall, 1201 patients (25%) developed a second skin cancer during follow-up; 1013 of the tumors were BCCs (21%), 154 were SCCs (3%), and 20 were melanomas (0.4%). The incidence was 107 per 1000 person-years (95% CI, 101-113) for any cancer, 90 per 1000 person-years (95% CI, 85-96) for BCC, 14 (95% CI, 12-16) per 1000 person-years for SCC, and 2 (95% CI, 1-3) per 1000 person-years for melanoma. More men than women developed a subsequent skin cancer (738 [61%] vs 463 [39%]). The main risk factors were a history of multiple tumors before diagnosis (relative risk [RR], 4.6; 95% CI, 2.9-7.1), immunosuppression (RR, 2.1; 95% CI, 1.4-3.1), and male sex (RR, 1.6; 95% CI, 1.4-1.9). Conclusion: patients have an increased risk of developing a second tumor after MMS treatment of NMSC. Risk factors are a history of multiple tumors at diagnosis, immunosuppression, and male sex.
  • dc.format.mimetype application/pdf
  • dc.identifier.citation Miñano Medrano R, López Estebaranz JL, Sanmartin-Jiménez O, Garcés JR, Rodríguez-Prieto MA, Vilarrasa-Rull E, et al. Risk of a second skin cancer in a cohort of patients with nonmelanoma skin cancer -basal cell carcinoma or squamous cell carcinoma-treated with mohs micrographic surgery: a national prospective cohort study. Actas Dermosifiliogr. 2022 May; 113(5): 451-8. DOI: 10.1016/j.ad.2022.01.035
  • dc.identifier.doi http://dx.doi.org/10.1016/j.ad.2022.01.035
  • dc.identifier.issn 0001-7310
  • dc.identifier.uri http://hdl.handle.net/10230/54250
  • dc.language.iso eng
  • dc.publisher Elsevier
  • dc.rights 0001-7310/© 2022 Published by Elsevier España, S.L.U. on behalf of AEDV. This is an open access Article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
  • dc.rights.accessRights info:eu-repo/semantics/openAccess
  • dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/4.0/
  • dc.subject.keyword Basal cell carcinoma
  • dc.subject.keyword Carcinoma basocelular
  • dc.subject.keyword Carcinoma epidermoide cutáneo
  • dc.subject.keyword Cirugía micrográfica de Mohs
  • dc.subject.keyword Factores de riesgo
  • dc.subject.keyword Incidence
  • dc.subject.keyword Incidencia
  • dc.subject.keyword Mohs micrographic surgery
  • dc.subject.keyword Risk factors
  • dc.subject.keyword Second cancer
  • dc.subject.keyword Segunda neoplasia
  • dc.subject.keyword Squamous cell carcinoma
  • dc.title Risk of a second skin cancer in a cohort of patients with nonmelanoma skin cancer -basal cell carcinoma or squamous cell carcinoma-treated with mohs micrographic surgery: a national prospective cohort study
  • dc.type info:eu-repo/semantics/article
  • dc.type.version info:eu-repo/semantics/publishedVersion

Col·leccions

Articles (Hospital del Mar Research Institute)