Rich club organization supports a diverse set of functional network configurations

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  • dc.contributor.author Senden, Marioca
  • dc.contributor.author Deco, Gustavoca
  • dc.contributor.author Reus, Marcel A. deca
  • dc.contributor.author Goebel, Rainerca
  • dc.contributor.author Heuvel, Martijn van denca
  • dc.date.accessioned 2015-02-12T08:19:25Z
  • dc.date.available 2015-02-12T08:19:25Z
  • dc.date.issued 2014ca
  • dc.description.abstract Brain function relies on the flexible integration of a diverse set of segregated cortical/nmodules, with the structural connectivity of the brain being a fundamentally important factor/nin shaping the brain‟s functional dynamics. Following up on macroscopic studies showing the/nexistence of centrally connected nodes in the mammalian brain, combined with the notion that/nthese putative brain hubs may form a dense interconnected „rich club‟ collective, we/nhypothesized that brain connectivity might involve a rich club type of architecture to promote/na repertoire of different and flexibly accessible brain functions. With the rich club suggested/nto play an important role in global brain communication, examining the effects of a rich club/norganization on the functional repertoire of physical systems in general, and the brain in/nparticular, is of keen interest. Here we elucidate these effects using a spin glass model of/nneural networks for simulating stable configurations of cortical activity. Using simulations,/nwe show that the presence of a rich club increases the set of attractors and hence the diversity/nof the functional repertoire over and above the effects produced by scale free type topology/nalone. Within the networks‟ overall functional repertoire rich nodes are shown to be important/nfor enabling a high level of dynamic integrations of low-degree nodes to form functional/nnetworks. This suggests that the rich club serves as an important backbone for numerous co-/nactivation patterns among peripheral nodes of the network. In addition, applying the spin/nglass model to empirical anatomical data of the human brain, we show that the positive effects/non the functional repertoire attributed to the rich club phenomenon can be observed for the/nbrain as well. We conclude that a rich club organization in network architectures may be/ncrucial for the facilitation and integration of a diverse number of segregated functions.en
  • dc.description.sponsorship Authors MS and RG were supported by the European Research Council under the European Union's Seventh Framework Programme (ERC-2010-AdG, ERC grant agreement no. 269853). Author GD was supported by the ERC Advanced Grant: DYSTRUCTURE (n. 295129), by the Spanish Research ProjectSAF2010-16085 and by European Community's Seventh Framework Programme under the project “BrainScales” (project number 269921). Author MPvdH was supported by a VENI grant of The Netherlands Organization for Scientific Research (NWO) (451-12-001) and by a Fellowship of the Brain Center Rudolf Magnus.
  • dc.format.mimetype application/pdfca
  • dc.identifier.citation Senden M, Deco G, de Reus MA, Goebel R, van den Heuvel MP. Rich club organization supports a diverse set of functional network configurations. NeuroImage. 2014 Aug;96:174–82. DOI 10.1016/j.neuroimage.2014.03.066ca
  • dc.identifier.doi http://dx.doi.org/10.1016/j.neuroimage.2014.03.066
  • dc.identifier.issn 1053-8119ca
  • dc.identifier.uri http://hdl.handle.net/10230/23126
  • dc.language.iso engca
  • dc.publisher Elsevierca
  • dc.relation.ispartof NeuroImage. 2014 Aug;96:174–82
  • dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/295129ca
  • dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/269853
  • dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/269921
  • dc.relation.projectID info:eu-repo/grantAgreement/ES/3PN/SAF2010-16085
  • dc.rights © Elsevier http://dx.doi.org/10.1016/j.neuroimage.2014.03.066ca
  • dc.rights.accessRights info:eu-repo/semantics/openAccessca
  • dc.subject.keyword Rich club
  • dc.subject.keyword Functional repertoire
  • dc.subject.keyword Connectivity
  • dc.subject.keyword Spin glass model
  • dc.subject.keyword Connectome
  • dc.title Rich club organization supports a diverse set of functional network configurationsca
  • dc.type info:eu-repo/semantics/articleca
  • dc.type.version info:eu-repo/semantics/acceptedVersionca

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