Association of cut-point free metrics and common clinical tests among older adults after proximal femoral fracture

Younesian, Hananeh; Singleton, David; Vereijken, Beatrix; García Aymerich, Judith; Rochester, Lynn; Aursand Berge, Martin; Engdal, Monika; Buekers, Joren; Koch, Sarah; Helbostad, Jorunn L.; Alvarez, Paula; Jansen, Carl-Philipp; Aminian, Kamiar; Paraschiv-Ionescu, Anisoara; Becker, Clemens; Caulfield, Brian; Mobilise-D consortium

Association of cut-point free metrics and common clinical tests among older adults after proximal femoral fracture

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dc.contributor.author Younesian, Hananeh
dc.contributor.author Singleton, David
dc.contributor.author Vereijken, Beatrix
dc.contributor.author García Aymerich, Judith
dc.contributor.author Rochester, Lynn
dc.contributor.author Aursand Berge, Martin
dc.contributor.author Engdal, Monika
dc.contributor.author Buekers, Joren
dc.contributor.author Koch, Sarah
dc.contributor.author Helbostad, Jorunn L.
dc.contributor.author Alvarez, Paula
dc.contributor.author Jansen, Carl-Philipp
dc.contributor.author Aminian, Kamiar
dc.contributor.author Paraschiv-Ionescu, Anisoara
dc.contributor.author Becker, Clemens
dc.contributor.author Caulfield, Brian
dc.contributor.author Mobilise-D consortium
dc.date.accessioned 2025-06-10T06:13:41Z
dc.date.available 2025-06-10T06:13:41Z
dc.date.issued 2025
dc.description.abstract Wearable and lightweight devices facilitate real-world physical activity (PA) assessments. MX metrics, as a cut-point-free parameter, evaluate acceleration above which the most active X minutes are accumulated. It provides insights into the intensity of PA over specific durations. This study evaluated the association of MX metrics and clinical tests in older adults recovering from proximal femoral fracture (PFF). Analyses were conducted on the PFF cohort from the baseline assessment of the Mobilise-D project using an accelerometer-based device. Participants (N = 396) were categorized into four recovery groups: acute, post-acute, extended recovery, and long-term recovery. Mobility capacity was assessed through the 6 min walking test (6MinWT), Short Physical Performance Battery (SPPB), 4-m walking test (4MWT), and hand grip (HG) strength. Mobility perception was evaluated using the Late-Life Function and Disability Instrument (LLFDI). Eight MX metrics (M1-M90) were calculated using the GGIR package in R. Results showed a moderate to strong positive correlation between M1 and M30 and lower limb mobility capacity tests and mobility perception (Lower Extremity domains) particularly in the extended and long-term recovery groups. MX metrics can be used for measuring PA intensity among older adults recovering from PFF. Hence, MX metrics have a high potential for clinical use as personalized PA targets in PFF rehabilitation.
dc.description.sponsorship H.Y. has received funding from the European Union’s Horizon 2020 research and innovation program under the Marie Skłodowska-Curie grant agreement No 101034252. This research is supported by Taighde Éireann—Research Ireland. The Mobilise-D consortium received funding from the Innovative Medicines Initiative 2 Joint Undertaking under grant agreement No 820820. This Joint Undertaking receives support from the European Union’s Horizon 2020 research and innovation program and EFPIA.
dc.format.mimetype application/pdf
dc.identifier.citation Younesian H, Singleton D, Vereijken B, Garcia-Aymerich J, Rochester L, Aursand Berge M, et al. Association of cut-point free metrics and common clinical tests among older adults after proximal femoral fracture. Sensors (Basel). 2025 Apr 18;25(8):2557. DOI: 10.3390/s25082557
dc.identifier.doi http://dx.doi.org/10.3390/s25082557
dc.identifier.issn 1424-8220
dc.identifier.uri http://hdl.handle.net/10230/70642
dc.language.iso eng
dc.publisher MDPI
dc.relation.ispartof Sensors (Basel). 2025 Apr 18;25(8):2557
dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/101034252
dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/820820
dc.rights © 2025 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.rights.uri http://creativecommons.org/licenses/by/4.0/
dc.subject.keyword LLFDI
dc.subject.keyword MX metrics
dc.subject.keyword Acceleration
dc.subject.keyword Clinical assessment
dc.subject.keyword Physical activity
dc.title Association of cut-point free metrics and common clinical tests among older adults after proximal femoral fracture
dc.type info:eu-repo/semantics/article
dc.type.version info:eu-repo/semantics/publishedVersion

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