Association of cut-point free metrics and common clinical tests among older adults after proximal femoral fracture

Younesian, Hananeh; Singleton, David; Vereijken, Beatrix; García Aymerich, Judith; Rochester, Lynn; Aursand Berge, Martin; Engdal, Monika; Buekers, Joren; Koch, Sarah; Helbostad, Jorunn L.; Alvarez, Paula; Jansen, Carl-Philipp; Aminian, Kamiar; Paraschiv-Ionescu, Anisoara; Becker, Clemens; Caulfield, Brian; Mobilise-D consortium

doi:http://dx.doi.org/10.3390/s25082557

Association of cut-point free metrics and common clinical tests among older adults after proximal femoral fracture

Citation

Younesian H, Singleton D, Vereijken B, Garcia-Aymerich J, Rochester L, Aursand Berge M, et al. Association of cut-point free metrics and common clinical tests among older adults after proximal femoral fracture. Sensors (Basel). 2025 Apr 18;25(8):2557. DOI: 10.3390/s25082557

Abstract

Wearable and lightweight devices facilitate real-world physical activity (PA) assessments. MX metrics, as a cut-point-free parameter, evaluate acceleration above which the most active X minutes are accumulated. It provides insights into the intensity of PA over specific durations. This study evaluated the association of MX metrics and clinical tests in older adults recovering from proximal femoral fracture (PFF). Analyses were conducted on the PFF cohort from the baseline assessment of the Mobilise-D project using an accelerometer-based device. Participants (N = 396) were categorized into four recovery groups: acute, post-acute, extended recovery, and long-term recovery. Mobility capacity was assessed through the 6 min walking test (6MinWT), Short Physical Performance Battery (SPPB), 4-m walking test (4MWT), and hand grip (HG) strength. Mobility perception was evaluated using the Late-Life Function and Disability Instrument (LLFDI). Eight MX metrics (M1-M90) were calculated using the GGIR package in R. Results showed a moderate to strong positive correlation between M1 and M30 and lower limb mobility capacity tests and mobility perception (Lower Extremity domains) particularly in the extended and long-term recovery groups. MX metrics can be used for measuring PA intensity among older adults recovering from PFF. Hence, MX metrics have a high potential for clinical use as personalized PA targets in PFF rehabilitation.