The human language effective connectome

Mostra el registre complet Registre parcial de l'ítem

• dc.contributor.author Rolls, Edmund T
• dc.contributor.author Deco, Gustavo
• dc.contributor.author Huang, Chu-Chung
• dc.contributor.author Feng, Jianfeng
• dc.date.accessioned 2023-03-01T13:51:58Z
• dc.date.available 2023-03-01T13:51:58Z
• dc.date.issued 2022
• dc.description.abstract To advance understanding of brain networks involved in language, the effective connectivity between 26 cortical regions implicated in language by a community analysis and 360 cortical regions was measured in 171 humans from the Human Connectome Project, and complemented with functional connectivity and diffusion tractography, all using the HCP multimodal parcellation atlas. A (semantic) network (Group 1) involving inferior cortical regions of the superior temporal sulcus cortex (STS) with the adjacent inferior temporal visual cortex TE1a and temporal pole TG, and the connected parietal PGi region, has effective connectivity with inferior temporal visual cortex (TE) regions; with parietal PFm which also has visual connectivity; with posterior cingulate cortex memory-related regions; with the frontal pole, orbitofrontal cortex, and medial prefrontal cortex; with the dorsolateral prefrontal cortex; and with 44 and 45 for output regions. It is proposed that this system can build in its temporal lobe (STS and TG) and parietal parts (PGi and PGs) semantic representations of objects incorporating especially their visual and reward properties. Another (semantic) network (Group 3) involving superior regions of the superior temporal sulcus cortex and more superior temporal lobe regions including STGa, auditory A5, TPOJ1, the STV and the Peri-Sylvian Language area (PSL) has effective connectivity with auditory areas (A1, A4, A5, Pbelt); with relatively early visual areas involved in motion, e.g., MT and MST, and faces/words (FFC); with somatosensory regions (frontal opercular FOP, insula and parietal PF); with other TPOJ regions; and with the inferior frontal gyrus regions (IFJa and IFSp). It is proposed that this system builds semantic representations specialising in auditory and related facial motion information useful in theory of mind and somatosensory / body image information, with outputs directed not only to regions 44 and 45, but also to premotor 55b and midcingulate premotor cortex. Both semantic networks (Groups 1 and 3) have access to the hippocampal episodic memory system via parahippocampal TF. A third largely frontal network (Group 2) (44, 45, 47l; 55b; the Superior Frontal Language region SFL; and including temporal pole TGv) receives effective connectivity from the two semantic systems, and is implicated in syntax and speech output.
• dc.description.sponsorship The research was supported by the following grants to Professor J. Feng: National Key R&D Program of China (No. 2019YFA0709502); 111 Project (No. B18015); Shanghai Municipal Science and Technology Major Project (No. 2018SHZDZX01), ZJLab, and Shanghai Center for Brain Science and Brain-Inspired Technology; and National Key R&D Program of China (No. 2018YFC1312904). G.D. is supported by a Spanish national research project (Ref. PID2019-105772GB-I00 MCIU AEI) funded by the Spanish Ministry of Science, Innovation and Universities (MCIU), State Research Agency (AEI); HBP SGA3 Human Brain Project Specific Grant Agreement 3 (grant agreement No. 945539), funded by the EU H2020 FET Flagship programme; SGR Research Support Group support (Ref. 2017 SGR 1545), funded by the Catalan Agency for Management of University and Research Grants (AGAUR); Neurotwin Digital twins for model-driven non-invasive electrical brain stimulation (grant agreement ID: 101017716) funded by the EU H2020 FET Proactive programme; euSNN European School of Network Neuroscience (grant agreement ID: 860563) funded by the EU H2020 MSCA-ITN Innovative Training Networks; CECH The Emerging Human Brain Cluster (Id. 001-P-001682) within the framework of the European Research Development Fund Operational Program of Catalonia 2014-2020; Brain-Connects: Brain Connectivity during Stroke Recovery and Rehabilitation (Id. 201725.33) funded by the Fundacio La Marato TV3; Corticity, FLAG˙˙ERA JTC 2017, (Ref. PCI2018-092891) funded by the Spanish Ministry of Science, Innovation and Universities (MCIU), State Research Agency (AEI).
• dc.format.mimetype application/pdf
• dc.identifier.citation Rolls ET, Deco G, Huang CC, Feng J. The human language effective connectome. Neuroimage. 2022;258:119352. DOI: 10.1016/j.neuroimage.2022.119352
• dc.identifier.doi http://dx.doi.org/10.1016/j.neuroimage.2022.119352
• dc.identifier.issn 1053-8119
• dc.identifier.uri http://hdl.handle.net/10230/56002
• dc.language.iso eng
• dc.publisher Elsevier
• dc.relation.ispartof NeuroImage. 2022;258:119352.
• dc.relation.isreferencedby https://www.github.com/decolab/Effective-Connectivity--Hopf
• dc.relation.isreferencedby https://ars.els-cdn.com/content/image/1-s2.0-S1053811922004712-mmc1.docx
• dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/860563
• dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/945539
• dc.relation.projectID info:eu-repo/grantAgreement/ES/2PE/PCI2018-092891
• dc.relation.projectID info:eu-repo/grantAgreement/ES/2PE/PID2019-105772GB-I00
• dc.rights © 2022 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/4.0/
• dc.subject.keyword Language
• dc.subject.keyword Effective connectivity
• dc.subject.keyword Functional connectivity
• dc.subject.keyword Diffusion tractography
• dc.subject.keyword Broca's area
• dc.subject.keyword Semantic networks
• dc.subject.keyword Syntax
• dc.title The human language effective connectome
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion