Integration and segregation manifolds in the brain ensure cognitive flexibility during tasks and rest

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  • dc.contributor.author Capouskova, Katerina
  • dc.contributor.author Zamora-López, Gorka
  • dc.contributor.author Kringelbach, Morten L.
  • dc.contributor.author Deco, Gustavo
  • dc.date.accessioned 2024-12-09T18:14:15Z
  • dc.date.available 2024-12-09T18:14:15Z
  • dc.date.issued 2023
  • dc.description.abstract Adapting to a constantly changing environment requires the human brain to flexibly switch among many demanding cognitive tasks, processing both specialized and integrated information associated with the activity in functional networks over time. In this study, we investigated the nature of the temporal alternation between segregated and integrated states in the brain during rest and six cognitive tasks using functional MRI. We employed a deep autoencoder to explore the 2D latent space associated with the segregated and integrated states. Our results show that the integrated state occupies less space in the latent space manifold compared to the segregated states. Moreover, the integrated state is characterized by lower entropy of occupancy than the segregated state, suggesting that integration plays a consolidating role, while segregation may serve as cognitive expertness. Comparing rest and the tasks, we found that rest exhibits higher entropy of occupancy, indicating a more random wandering of the mind compared to the expected focus during task performance. Our study demonstrates that both transient, short-lived integrated and segregated states are present during rest and task performance, flexibly switching between them, with integration serving as information compression and segregation related to information specialization.
  • dc.description.sponsorship K. C, G. Z.-L., and G. D. are supported by the HBP SGA3 Human Brain Project Specific Grant Agreement 3 (grant agreement no. 945539), funded by the EU H2020 FET Flagship Programme; G. D. is supported by Project PID2022-136216NB-I00 financed by the MCIN / AEI/ 1013039 / 501100011033 / FEDER, UE., the Ministry of Science and Innovation, the State Research Agency and the European Regional Developmental Fund, and by AGAUR research support grant (ref. 2021 SGR 00917) funded by the Department of Research and Universities of the Generalitat of Catalunya. M. L. K. is supported by the ERC Consolidator Grant: CAREGIVING (No. 615539), Center for Music in the Brain, funded by the Danish National Research Foundation (DNRF117), and Centre for Eudaimonia and Human Flourishing funded by the Pettit and Carlsberg Foundations. The funding bodies had neither influence in the research design, data collection, and analysis nor will in preparing and publishing the manuscript.
  • dc.format.mimetype application/pdf
  • dc.identifier.citation Capouskova K, Zamora-López G, Kringelbach ML, Deco G. Integration and segregation manifolds in the brain ensure cognitive flexibility during tasks and rest. Hum Brain Mapp. 2023 Dec 15;44(18):6349-63. DOI: 10.1002/hbm.26511
  • dc.identifier.doi http://dx.doi.org/10.1002/hbm.26511
  • dc.identifier.issn 1065-9471
  • dc.identifier.uri http://hdl.handle.net/10230/68962
  • dc.language.iso eng
  • dc.publisher Wiley
  • dc.relation.ispartof Human Brain Mapping. 2023 Dec 15;44(18):6349-63
  • dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/945539
  • dc.relation.projectID info:eu-repo/grantAgreement/ES/3PE/PID2022-136216NB-I00
  • dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/615539
  • dc.rights © 2023 The Authors. Human Brain Mapping published by Wiley Periodicals LLC. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
  • dc.rights.accessRights info:eu-repo/semantics/openAccess
  • dc.rights.uri http://creativecommons.org/licenses/by-nc/4.0/
  • dc.subject.keyword Brain states
  • dc.subject.keyword fMRI
  • dc.subject.keyword HCP data set
  • dc.subject.keyword Integration
  • dc.subject.keyword Latent space
  • dc.subject.keyword Manifold
  • dc.subject.keyword Segregation
  • dc.title Integration and segregation manifolds in the brain ensure cognitive flexibility during tasks and rest
  • dc.type info:eu-repo/semantics/article
  • dc.type.version info:eu-repo/semantics/publishedVersion

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