Lipid and inflammatory biomarker profiles in early insulin resistance.

Marcelino Rodríguez, Itahisa; Oliva García, José Gregorio; Alemán Sánchez, José Juan; Almeida  González, Delia; Domínguez  Coello, Santiago; Brito Díaz, Buenaventura; Gannar, Fadoua; Rodríguez Pérez, María del Cristo; Elosua Llanos, Roberto; Cabrera de León, Antonio

doi:http://dx.doi.org/10.1007/s00592-016-0885-6

Lipid and inflammatory biomarker profiles in early insulin resistance.

Citació

Marcelino Rodríguez I, Oliva García J, Alemán Sánchez JJ, Almeida González D, Domínguez Coello S, Brito Díaz B. et al. Lipid and inflammatory biomarker profiles in early insulin resistance. Acta Diabetol. 2016 Dec;53(6):905-913

Resum

AIMS: To analyze the serum lipid and inflammatory biomarker profile in the early insulin resistance (e-IR). METHODS: Cross-sectional study of 5943 adults without diabetes, stratified into no IR group (C-peptide <third tertile and glucose <100 mg/dL), e-IR group (C-peptide ≥third tertile and glucose <100 mg/dL) and advanced IR group (glucose ≥100 mg/dL). RESULTS: E-IR showed significant differences with no IR in the serum concentration of triglycerides (P < 0.001), HDL cholesterol (P < 0.001), LDL cholesterol (P < 0.001), sCD40L (P < 0.001), C-reactive protein (P < 0.004), leptin (P < 0.001) and adiponectin (P < 0.001). Adjusting for age, gender and abdominal obesity, corroborated the association of e-IR with highest quintile of triglycerides (OR 3.88 [3.07-4.89]), HDL cholesterol (OR 0.35 [0.28-0.44]), sCD40L (OR 0.47 [0.24-0.94]), C-reactive protein (OR 2.31 [1.29-4.12]), adiponectin (OR 0.11 [0.04-0.32]), PAI-1 (OR 3.29 [1.29-8.40]) and resistin (OR 1.25 [1.01-1.54]); the same biomarkers were associated with advanced IR although resistin was a protective factor (OR 0.73 [0.58-0.93]). CONCLUSIONS: Euglycemic patients with e-IR present an unfavorable serum lipid and inflammatory biomarker profile. Measuring C-peptide in euglycemic patients with elevated triglycerides identifies e-IR.