Lipid and inflammatory biomarker profiles in early insulin resistance.

Marcelino Rodríguez, Itahisa; Oliva García, José Gregorio; Alemán Sánchez, José Juan; Almeida  González, Delia; Domínguez  Coello, Santiago; Brito Díaz, Buenaventura; Gannar, Fadoua; Rodríguez Pérez, María del Cristo; Elosua Llanos, Roberto; Cabrera de León, Antonio

Lipid and inflammatory biomarker profiles in early insulin resistance.

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dc.contributor.author Marcelino Rodríguez, Itahisaca
dc.contributor.author Oliva García, José Gregorioca
dc.contributor.author Alemán Sánchez, José Juanca
dc.contributor.author Almeida González, Deliaca
dc.contributor.author Domínguez Coello, Santiagoca
dc.contributor.author Brito Díaz, Buenaventuraca
dc.contributor.author Gannar, Fadouaca
dc.contributor.author Rodríguez Pérez, María del Cristoca
dc.contributor.author Elosua Llanos, Robertoca
dc.contributor.author Cabrera de León, Antonioca
dc.date.accessioned 2017-02-27T09:22:37Z
dc.date.available 2017-02-27T09:22:37Z
dc.date.issued 2016
dc.description.abstract AIMS: To analyze the serum lipid and inflammatory biomarker profile in the early insulin resistance (e-IR). METHODS: Cross-sectional study of 5943 adults without diabetes, stratified into no IR group (C-peptide <third tertile and glucose <100 mg/dL), e-IR group (C-peptide ≥third tertile and glucose <100 mg/dL) and advanced IR group (glucose ≥100 mg/dL). RESULTS: E-IR showed significant differences with no IR in the serum concentration of triglycerides (P < 0.001), HDL cholesterol (P < 0.001), LDL cholesterol (P < 0.001), sCD40L (P < 0.001), C-reactive protein (P < 0.004), leptin (P < 0.001) and adiponectin (P < 0.001). Adjusting for age, gender and abdominal obesity, corroborated the association of e-IR with highest quintile of triglycerides (OR 3.88 [3.07-4.89]), HDL cholesterol (OR 0.35 [0.28-0.44]), sCD40L (OR 0.47 [0.24-0.94]), C-reactive protein (OR 2.31 [1.29-4.12]), adiponectin (OR 0.11 [0.04-0.32]), PAI-1 (OR 3.29 [1.29-8.40]) and resistin (OR 1.25 [1.01-1.54]); the same biomarkers were associated with advanced IR although resistin was a protective factor (OR 0.73 [0.58-0.93]). CONCLUSIONS: Euglycemic patients with e-IR present an unfavorable serum lipid and inflammatory biomarker profile. Measuring C-peptide in euglycemic patients with elevated triglycerides identifies e-IR.ca
dc.description.sponsorship Funding Canary Islands Health Service. Spanish Government (Instituto de Salud Carlos III, Projects 0901314, PI12/01855, and RD12/0042/0031 and 0013. FEDER).
dc.format.mimetype application/pdfca
dc.identifier.citation Marcelino Rodríguez I, Oliva García J, Alemán Sánchez JJ, Almeida González D, Domínguez Coello S, Brito Díaz B. et al. Lipid and inflammatory biomarker profiles in early insulin resistance. Acta Diabetol. 2016 Dec;53(6):905-913ca
dc.identifier.doi http://dx.doi.org/10.1007/s00592-016-0885-6
dc.identifier.issn 0940-5429
dc.identifier.uri http://hdl.handle.net/10230/28141
dc.language.iso engca
dc.publisher Springerca
dc.relation.ispartof Acta Diabetologica. 2016 Dec;53(6):905-13
dc.rights.accessRights info:eu-repo/semantics/embargoedAccessca
dc.subject.other Insulinaca
dc.subject.other Marcadors bioquímicsca
dc.subject.other Lípidsca
dc.title Lipid and inflammatory biomarker profiles in early insulin resistance.ca
dc.type info:eu-repo/semantics/articleca
dc.type.version info:eu-repo/semantics/acceptedVersionca

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