Rate and oscillatory switching dynamics of a multilayer visual microcircuit model

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  • dc.contributor.author Hahn, Gerald
  • dc.contributor.author Kumar, Arvind
  • dc.contributor.author Schmidt, Helmut
  • dc.contributor.author Knösche, Thomas R.
  • dc.contributor.author Deco, Gustavo
  • dc.date.accessioned 2023-03-03T07:43:03Z
  • dc.date.available 2023-03-03T07:43:03Z
  • dc.date.issued 2022
  • dc.description.abstract The neocortex is organized around layered microcircuits consisting of a variety of excitatory and inhibitory neuronal types which perform rate- and oscillation-based computations. Using modeling, we show that both superficial and deep layers of the primary mouse visual cortex implement two ultrasensitive and bistable switches built on mutual inhibitory connectivity motives between somatostatin, parvalbumin, and vasoactive intestinal polypeptide cells. The switches toggle pyramidal neurons between high and low firing rate states that are synchronized across layers through translaminar connectivity. Moreover, inhibited and disinhibited states are characterized by low- and high-frequency oscillations, respectively, with layer-specific differences in frequency and power which show asymmetric changes during state transitions. These findings are consistent with a number of experimental observations and embed firing rate together with oscillatory changes within a switch interpretation of the microcircuit.
  • dc.description.sponsorship G.H., H.S., T.R.K., and G.D. were funded by the German Research Council (DFG, No. KN 588/7-1) within the priority program Computational Connectomics (SPP 2041). G.D. was supported by the Spanish Research Project AWAKENING: using whole-brain models perturbational approaches for predicting external stimulation to force transitions between different brain states, ref: PID2019-105772GB-I00 /AEI/10.13039/501100011033, financed by the Spanish Ministry of Science, Innovation and Universities (MCIU), the Spanish Research Project COBRAS PSI2016-75688-P (AEI/FEDER, EU), and by the Catalan AGAUR program 2017 SGR 1545. G.D. and G.H. received support from the European Union’s Horizon 2020 research and innovation program under Grant Agreement No. 720,270 (Human Brain Project SGA1) and No. 785,907 (Human Brain Project SGA2). G.H. was funded by the grant CONSCBRAIN (n. 661583) of the European Union’s Horizon 2020 research and innovation program under the Marie Skłodowska-Curie action. A.K. received support from the Swedish Research Council.
  • dc.format.mimetype application/pdf
  • dc.identifier.citation Hahn G, Kumar A, Schmidt H, Knösche TR, Deco G. Rate and oscillatory switching dynamics of a multilayer visual microcircuit model. eLife. 2022;11:e77594. DOI: 10.7554/eLife.77594
  • dc.identifier.doi http://dx.doi.org/10.7554/eLife.77594
  • dc.identifier.issn 2050-084X
  • dc.identifier.uri http://hdl.handle.net/10230/56021
  • dc.language.iso eng
  • dc.publisher eLife
  • dc.relation.ispartof eLife. 2022;11:e77594.
  • dc.relation.isreferencedby https://cdn.elifesciences.org/articles/77594/elife-77594-supp1-v1.docx
  • dc.relation.isreferencedby https://cdn.elifesciences.org/articles/77594/elife-77594-transrepform1-v1.docx
  • dc.relation.isreferencedby https://cdn.elifesciences.org/articles/77594/elife-77594-code1-v1.zip
  • dc.relation.isreferencedby https://cdn.elifesciences.org/articles/77594/elife-77594-code2-v1.zip
  • dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/720270
  • dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/785907
  • dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/661583
  • dc.relation.projectID info:eu-repo/grantAgreement/ES/2PE/PID2019-105772GB-I00
  • dc.relation.projectID info:eu-repo/grantAgreement/ES/1PE/PSI2016-75688-P
  • dc.rights © Hahn et al. This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited.
  • dc.rights.accessRights info:eu-repo/semantics/openAccess
  • dc.rights.uri http://creativecommons.org/licenses/by/4.0/
  • dc.subject.keyword neuroscience
  • dc.subject.keyword microcircuit
  • dc.subject.keyword modeling
  • dc.subject.keyword oscillations
  • dc.subject.keyword switching dynamics
  • dc.subject.keyword cortical layers
  • dc.title Rate and oscillatory switching dynamics of a multilayer visual microcircuit model
  • dc.type info:eu-repo/semantics/article
  • dc.type.version info:eu-repo/semantics/publishedVersion

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