A ventromedial visual cortical ‘Where’ stream to the human hippocampus for spatial scenes revealed with magnetoencephalography

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• dc.contributor.author Rolls, Edmund T.
• dc.contributor.author Yan, Xiaoqian
• dc.contributor.author Deco, Gustavo
• dc.contributor.author Jousmaki, Veikko
• dc.contributor.author Feng, Jianfeng
• dc.date.accessioned 2025-05-20T07:55:25Z
• dc.date.available 2025-05-20T07:55:25Z
• dc.date.issued 2024
• dc.description.abstract The primate including the human hippocampus implicated in episodic memory and navigation represents a spatial view, very different from the place representations in rodents. To understand this system in humans, and the computations performed, the pathway for this spatial view information to reach the hippocampus was analysed in humans. Whole-brain effective connectivity was measured with magnetoencephalography between 30 visual cortical regions and 150 other cortical regions using the HCP-MMP1 atlas in 21 participants while performing a 0-back scene memory task. In a ventromedial visual stream, V1–V4 connect to the ProStriate region where the retrosplenial scene area is located. The ProStriate region has connectivity to ventromedial visual regions VMV1–3 and VVC. These ventromedial regions connect to the medial parahippocampal region PHA1–3, which, with the VMV regions, include the parahippocampal scene area. The medial parahippocampal regions have effective connectivity to the entorhinal cortex, perirhinal cortex, and hippocampus. In contrast, when viewing faces, the effective connectivity was more through a ventrolateral visual cortical stream via the fusiform face cortex to the inferior temporal visual cortex regions TE2p and TE2a. A ventromedial visual cortical ‘Where’ stream to the hippocampus for spatial scenes was supported by diffusion topography in 171 HCP participants at 7 T.
• dc.description.sponsorship The neuroimaging data used for the diffusion tractography were provided by the HCP, WU-Minn Consortium (Principal Investigators: David Van Essen and Kamil Ugurbil; 1U54MH091657) funded by the 16 NIH Institutes and Centres that support the NIH Blueprint for Neuroscience Research; and by the McDonnell Center for Systems Neuroscience at Washington University. The research described here was supported by the following grants. Professor J. Feng: National Key R&D Programme of China (No. 2019YFA0709502); 111 Project (No. B18015); Shanghai Municipal Science and Technology Major Project (No. 2018SHZDZX01), ZJLab, and Shanghai Center for Brain Science and Brain-Inspired Technology; and National Key R&D Programme of China (No. 2018YFC1312904). G.D. is supported by a Spanish national research project (ref. PID2019-105772GB-I00 MCIU AEI) funded by the Spanish Ministry of Science, Innovation and Universities (MCIU), State Research Agency (AEI); HBP SGA3 Human Brain Project Specific Grant Agreement 3 (grant agreement no. 945539), funded by the EU H2020 FET Flagship programme; SGR Research Support Group support (ref. 2017 SGR 1545), funded by the Catalan Agency for Management of University and Research Grants (AGAUR); Neurotwin Digital twins for model-driven non-invasive electrical brain stimulation (grant agreement ID: 101017716) funded by the EU H2020 FET Proactive programme; euSNN European School of Network Neuroscience (grant agreement ID: 860563) funded by the EU H2020 MSCA-ITN Innovative Training Networks; CECH The Emerging Human Brain Cluster (Id. 001-P-001682) within the framework of the European Research Development Fund Operational Programme of Catalonia 2014-2020; Brain-Connects: Brain Connectivity during Stroke Recovery and Rehabilitation (id. 201725.33) funded by the Fundacio La Marato TV3; Corticity, FLAG˙˙ERA JTC 2017, (ref. PCI2018-092891) funded by the Spanish MCIU, State Research Agency (AEI). The funding sources had no role in the study design; in the collection, analysis and interpretation of data; in the writing of the report; and in the decision to submit the article for publication.
• dc.format.mimetype application/pdf
• dc.identifier.citation Rolls ET, Yan X, Deco G, Zhang Y, Jousmaki V, Feng J. A ventromedial visual cortical ‘Where’ stream to the human hippocampus for spatial scenes revealed with magnetoencephalography. Commun Biol. 2024;7:1047. DOI: 10.1038/s42003-024-06719-z
• dc.identifier.doi http://dx.doi.org/10.1038/s42003-024-06719-z
• dc.identifier.issn 2399-3642
• dc.identifier.uri http://hdl.handle.net/10230/70438
• dc.language.iso eng
• dc.publisher Nature Research
• dc.relation.ispartof Communications Biology. 2024;7:1047
• dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/945539
• dc.relation.projectID info:eu-repo/grantAgreement/ES/2PE/PID2019-105772GB-I00
• dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/860563
• dc.relation.projectID info:eu-repo/grantAgreement/ES/2PE/PCI2018-092891
• dc.rights © The Author(s) 2024. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by/4.0/
• dc.subject.other Hipocamp
• dc.subject.other Xarxes neuronals (Neurobiologia)
• dc.title A ventromedial visual cortical ‘Where’ stream to the human hippocampus for spatial scenes revealed with magnetoencephalography
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion