Novel fingerprinting method characterises the necessary and sufficient structural connectivity from deep brain stimulation electrodes for a successful outcome

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  • dc.contributor.author Fernandes, Henrique M.ca
  • dc.contributor.author Van Hartevelt, Tim J.ca
  • dc.contributor.author Boccard, Sandra G Jca
  • dc.contributor.author Owen, Sarah L. F.ca
  • dc.contributor.author Cabral, Joanaca
  • dc.contributor.author Deco, Gustavoca
  • dc.contributor.author Green, Alex L.ca
  • dc.contributor.author FitzGerald, James J.ca
  • dc.contributor.author Aziz, Tipu Z.ca
  • dc.contributor.author Kringelbach, Morten L.ca
  • dc.date.accessioned 2015-10-01T07:08:55Z
  • dc.date.available 2015-10-01T07:08:55Z
  • dc.date.issued 2015ca
  • dc.description.abstract Deep brain stimulation (DBS) is a remarkably effective clinical tool, used primarily for movement/ndisorders. DBS relies on precise targeting of specific brain regions to rebalance the oscillatory behaviour/nof whole-brain neural networks. Traditionally, DBS targeting has been based upon animal/nmodels (such asMPTPfor Parkinson’s disease) but has also been the result of serendipity during/nhuman lesional neurosurgery. There are, however, no good animal models of psychiatric disorders/nsuch as depression and schizophrenia, and progress in this area has been slow. In this paper, we use/nadvanced tractography combined with whole-brain anatomical parcellation to provide a rational/nfoundation for identifying the connectivity ‘fingerprint’ of existing, successful DBS targets. This/nknowledge can then be used pre-surgically and even potentially for the discovery of novel targets. First,/nusing data from our recent case series of cingulate DBS for patients with treatment-resistant chronic/npain, we demonstrate how to identify the structural ‘fingerprints’ of existing successful and unsuccessful/nDBS targets in terms of their connectivity to other brain regions, as defined by the whole-brain/nanatomical parcellation. Second, we use a number of different strategies to identify the successful fingerprints/nof structural connectivity across four patients with successful outcomes compared with/ntwo patients with unsuccessful outcomes. This fingerprinting method can potentially be used presurgically/nto account for a patient’s individual connectivity and identify the best DBS target. Ultimately,/nour novel fingerprinting method could be combined with advanced whole-brain computational/nmodelling of the spontaneous dynamics arising from the structural changes in disease, to/nprovide new insights and potentially new targets for hitherto impenetrable neuropsychiatric/ndisorders.en
  • dc.description.sponsorship We thank Ms Eloise Starkfor her valuable comments. MLK was supported by the ERC ConsolidatorGrant:/nCAREGIVING (n. 615539) and the TrygFonden Charitable Foundation. GD was supported by the ERC Advanced/nGrant: DYSTRUCTURE (n. 295129), by the Spanish Research Project SAF2010-16085 and the FP7-ICT BrainScales.
  • dc.format.mimetype application/pdfca
  • dc.identifier.citation Fernandes HM, Van Hartevelt TJ, Boccard SGJ, Owen SLF, Cabral J, Deco G et al. Novel fingerprinting method characterises the necessary and sufficient structural connectivity from deep brain stimulation electrodes for a successful outcome. New Journal of Physics. 2015;17. DOI: 10.1088/1367-2630/17/1/015001.ca
  • dc.identifier.doi http://dx.doi.org/10.1088/1367-2630/17/1/015001
  • dc.identifier.issn 1367-2630ca
  • dc.identifier.uri http://hdl.handle.net/10230/24786
  • dc.language.iso engca
  • dc.publisher Institute of Physics (IOP)ca
  • dc.relation.ispartof New Journal of Physics. 2015;17.
  • dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/295129ca
  • dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/269921
  • dc.relation.projectID info:eu-repo/grantAgreement/ES/3PN/SAF2010-16085
  • dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/615539
  • dc.rights Content from this work may be used under the terms of the Creative Commons Attribution 3.0 licence.ca
  • dc.rights.accessRights info:eu-repo/semantics/openAccessca
  • dc.rights.uri http://creativecommons.org/licenses/by/3.0/
  • dc.subject.keyword Deep brain stimulationen
  • dc.subject.keyword Fingerprinten
  • dc.subject.keyword Diffusion imaging
  • dc.title Novel fingerprinting method characterises the necessary and sufficient structural connectivity from deep brain stimulation electrodes for a successful outcomeca
  • dc.type info:eu-repo/semantics/articleca
  • dc.type.version info:eu-repo/semantics/publishedVersionca

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